Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure

Cailey Banken, Autumn N. Harris, Rachel Conway, Eduardo J. Benjamin, Robin Shoemaker, Darcy Adin

Research output: Contribution to journalArticlepeer-review

Abstract

A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.

Original languageEnglish
Pages (from-to)3255-3260
Number of pages6
JournalJournal of Veterinary Internal Medicine
Volume38
Issue number6
DOIs
StatePublished - Nov 1 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.

Keywords

  • RAAS
  • diuretics
  • electrolytes
  • hypochloremia

ASJC Scopus subject areas

  • General Veterinary

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