Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure

Cailey Banken; Autumn N. Harris; Rachel Conway; Eduardo J. Benjamin; Robin Shoemaker; Darcy Adin

doi:10.1111/jvim.17238

Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure

Cailey Banken
, Autumn N. Harris
, Rachel Conway
, Eduardo J. Benjamin
, Robin Shoemaker
, Darcy Adin

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.

Original language	English
Pages (from-to)	3255-3260
Number of pages	6
Journal	Journal of Veterinary Internal Medicine
Volume	38
Issue number	6
DOIs	https://doi.org/10.1111/jvim.17238
State	Published - Nov 1 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.

Funding

Funding provided by the University of Kentucky RAS Analytical Laboratory. The authors thank Courtney Hanner and Alexis Cooper for technical support. We thank the University of Kentucky Mass Spectrometry and Proteomics Core Facility for analysis, supported in part by the Office of the Vice President for Research.

Funders
University of Kentucky RAS Analytical Laboratory
University of Kentucky Mass Spectrometry and Proteomics Core Facility
Office of the Executive Vice President for Research and Partnerships, Purdue University

Keywords

RAAS
diuretics
electrolytes
hypochloremia

ASJC Scopus subject areas

General Veterinary

Access to Document

10.1111/jvim.17238

Cite this

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title = "Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure",

abstract = "A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.",

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AU - Shoemaker, Robin

AU - Adin, Darcy

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AB - A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.

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Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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