Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

D. Larry Sparks, John C. Hunsaker, Stephen W. Scheff, Richard J. Kryscio, Jana L. Henson, William R. Markesbery

Research output: Contribution to journalArticlepeer-review

276 Scopus citations

Abstract

Mild alterations in cognitive function are present in normal aging and severe cognitive alterations are a hallmark of Alzheimer's disease (AD). The cognitive change in AD has been correlated to the characteristic pathologic lesions in the brain, senile plaques (SP) and neurofibrillary tangles. Senile plaques are the most consistent correlative marker in AD. We present preliminary data indicating that abundant SP are found in the brains of nondemented patients dying with or as a result of critical coronary artery disease (cCAD) compared to nonheart disease (non-HD) subjects; 15 of 20 cCAD patients contained SP and only two of 16 non-HD patients contained SP.

Original languageEnglish
Pages (from-to)601-607
Number of pages7
JournalNeurobiology of Aging
Volume11
Issue number6
DOIs
StatePublished - 1990

Bibliographical note

Funding Information:
This research was supported by grants from the Alzheimer's Association (IIRG-87-042; I1-078-87) and the NIH (1-PO1-AG05119; 1-P50-AG05144).

Funding

This research was supported by grants from the Alzheimer's Association (IIRG-87-042; I1-078-87) and the NIH (1-PO1-AG05119; 1-P50-AG05144).

FundersFunder number
National Institutes of Health (NIH)1-P50-AG05144
National Institutes of Health (NIH)
National Institute on AgingP01AG005119
National Institute on Aging
Alzheimer's AssociationIIRG-87-042, I1-078-87
Alzheimer's Association

    Keywords

    • Alzheimer's disease
    • Coronary artery disease
    • Heart disease
    • Neuropathology of the Alzheimer's type
    • Senile plaques

    ASJC Scopus subject areas

    • General Neuroscience
    • Aging
    • Clinical Neurology
    • Developmental Biology
    • Geriatrics and Gerontology

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