Abstract
Mild alterations in cognitive function are present in normal aging and severe cognitive alterations are a hallmark of Alzheimer's disease (AD). The cognitive change in AD has been correlated to the characteristic pathologic lesions in the brain, senile plaques (SP) and neurofibrillary tangles. Senile plaques are the most consistent correlative marker in AD. We present preliminary data indicating that abundant SP are found in the brains of nondemented patients dying with or as a result of critical coronary artery disease (cCAD) compared to nonheart disease (non-HD) subjects; 15 of 20 cCAD patients contained SP and only two of 16 non-HD patients contained SP.
Original language | English |
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Pages (from-to) | 601-607 |
Number of pages | 7 |
Journal | Neurobiology of Aging |
Volume | 11 |
Issue number | 6 |
DOIs | |
State | Published - 1990 |
Bibliographical note
Funding Information:This research was supported by grants from the Alzheimer's Association (IIRG-87-042; I1-078-87) and the NIH (1-PO1-AG05119; 1-P50-AG05144).
Funding
This research was supported by grants from the Alzheimer's Association (IIRG-87-042; I1-078-87) and the NIH (1-PO1-AG05119; 1-P50-AG05144).
Funders | Funder number |
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National Institutes of Health (NIH) | 1-P50-AG05144 |
National Institutes of Health (NIH) | |
National Institute on Aging | P01AG005119 |
National Institute on Aging | |
Alzheimer's Association | IIRG-87-042, I1-078-87 |
Alzheimer's Association |
Keywords
- Alzheimer's disease
- Coronary artery disease
- Heart disease
- Neuropathology of the Alzheimer's type
- Senile plaques
ASJC Scopus subject areas
- General Neuroscience
- Aging
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology