Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study

James E. Mitchell, Wendy C. King, Jia Yuh Chen, Michael J. Devlin, David Flum, Luis Garcia, William Inabet, John R. Pender, Melissa A. Kalarchian, Saurabh Khandelwal, Marsha D. Marcus, Beth Schrope, Gladys Strain, Bruce Wolfe, Susan Yanovski

Research output: Contribution to journalArticlepeer-review

148 Scopus citations


Objective To examine changes in depressive symptoms and treatment in the first 3 years following bariatric surgery. Methods The longitudinal assessment of bariatric surgery-2 (LABS-2) is an observational cohort study of adults (n = 2,458) who underwent a bariatric surgical procedure at 1 of 10 US hospitals between 2006 and 2009. This study includes 2,148 participants who completed the Beck depression inventory (BDI) at baseline and ≥ one follow-up visit in years 1-3. Results At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score ≥ 10) were reported by 28.3%; moderate (BDI score 19-29) and severe (BDI score ≥30) symptoms were uncommon (4.2 and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR = 1.75; P = 0.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1year; 12.2%, 2 years; 15.6%, 3 years; ps < 0.001), but increased between 1 and 3 years postoperatively (P < 0.01). Change in depressive symptoms was significantly related to change in body mass index (r = 0.42; P < 0001). Conclusion Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year. LABS-2, #NCT00465829, http://www.

Original languageEnglish
Pages (from-to)1799-1806
Number of pages8
Issue number8
StatePublished - Aug 2014


  • Roux-en-Y gastric bypass
  • antidepressant medication
  • depression
  • laparoscopic adjustable gastric band
  • severe obesity
  • treatment
  • weight loss

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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