TY - JOUR
T1 - Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study
AU - Mitchell, James E.
AU - King, Wendy C.
AU - Chen, Jia Yuh
AU - Devlin, Michael J.
AU - Flum, David
AU - Garcia, Luis
AU - Inabet, William
AU - Pender, John R.
AU - Kalarchian, Melissa A.
AU - Khandelwal, Saurabh
AU - Marcus, Marsha D.
AU - Schrope, Beth
AU - Strain, Gladys
AU - Wolfe, Bruce
AU - Yanovski, Susan
PY - 2014/8
Y1 - 2014/8
N2 - Objective To examine changes in depressive symptoms and treatment in the first 3 years following bariatric surgery. Methods The longitudinal assessment of bariatric surgery-2 (LABS-2) is an observational cohort study of adults (n = 2,458) who underwent a bariatric surgical procedure at 1 of 10 US hospitals between 2006 and 2009. This study includes 2,148 participants who completed the Beck depression inventory (BDI) at baseline and ≥ one follow-up visit in years 1-3. Results At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score ≥ 10) were reported by 28.3%; moderate (BDI score 19-29) and severe (BDI score ≥30) symptoms were uncommon (4.2 and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR = 1.75; P = 0.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1year; 12.2%, 2 years; 15.6%, 3 years; ps < 0.001), but increased between 1 and 3 years postoperatively (P < 0.01). Change in depressive symptoms was significantly related to change in body mass index (r = 0.42; P < 0001). Conclusion Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year. LABS-2, #NCT00465829, http://www. clinicaltrials.gov/ct2/show/NCT00465829.
AB - Objective To examine changes in depressive symptoms and treatment in the first 3 years following bariatric surgery. Methods The longitudinal assessment of bariatric surgery-2 (LABS-2) is an observational cohort study of adults (n = 2,458) who underwent a bariatric surgical procedure at 1 of 10 US hospitals between 2006 and 2009. This study includes 2,148 participants who completed the Beck depression inventory (BDI) at baseline and ≥ one follow-up visit in years 1-3. Results At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score ≥ 10) were reported by 28.3%; moderate (BDI score 19-29) and severe (BDI score ≥30) symptoms were uncommon (4.2 and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR = 1.75; P = 0.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1year; 12.2%, 2 years; 15.6%, 3 years; ps < 0.001), but increased between 1 and 3 years postoperatively (P < 0.01). Change in depressive symptoms was significantly related to change in body mass index (r = 0.42; P < 0001). Conclusion Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year. LABS-2, #NCT00465829, http://www. clinicaltrials.gov/ct2/show/NCT00465829.
KW - Roux-en-Y gastric bypass
KW - antidepressant medication
KW - depression
KW - laparoscopic adjustable gastric band
KW - severe obesity
KW - treatment
KW - weight loss
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U2 - 10.1002/oby.20738
DO - 10.1002/oby.20738
M3 - Article
C2 - 24634371
AN - SCOPUS:84905011019
VL - 22
SP - 1799
EP - 1806
IS - 8
ER -
