Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function

doi:10.14336/AD.2023.0321-2

Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function

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10 Scopus citations

Abstract

The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from the MarkVCID consortium were included in this study. Two pipelines by using DSI studio and FSL software were developed for data processing and ALPS index calculation. The ALPS index was obtained by the average of bilateral ALPS index and was used for testing the cross-vendor, inter-rater and test-retest reliability by using R studio software. The ALPS index demonstrated favorable inter-scanner reproducibility (ICC=0.77 to 0.95, P< 0.001), inter-rater reliability (ICC=0.96 to 1, P< 0.001) and test-retest repeatability (ICC=0.89 to 0.95, P< 0.001), offering a potential biomarker for in vivo evaluation of GS function.

Original language	English
Pages (from-to)	1885-1898
Number of pages	14
Journal	Aging and Disease
Volume	15
Issue number	4
DOIs	https://doi.org/10.14336/AD.2023.0321-2
State	Published - Aug 1 2024

Bibliographical note

Publisher Copyright:
Copyright: © 2023 Liu X. et al.

Funding

The authors thank the participants in this study and the support of MarkVCID consortium. This study was supported by NIH grants UF1-NS100614, U24NS1 00591, UF1NS100599, UF1NS100588, UF1NS100608, UF1NS100605, UF1NS100606, UF1NS100598, P30AG 010129, P30AG072946, P30AG066530, UF1NS125513, P30AG066546.

Funders	Funder number
NIH	UF1NS100608, UF1NS100606, UF1-NS100614, P30AG 010129, P30AG066546, U24NS1 00591, UF1NS100605, P30AG066530, UF1NS125513, UF1NS100598, P30AG072946, UF1NS100588, UF1NS100599

Keywords

Brain
Diffusion tensor image analysis along the perivascular space (DTI-ALPS)
MarkVCID consortium
Neurofluids
glymphatic system

ASJC Scopus subject areas

Pathology and Forensic Medicine
Geriatrics and Gerontology
Clinical Neurology
Cell Biology

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10.14336/AD.2023.0321-2

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title = "Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function",

abstract = "The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from the MarkVCID consortium were included in this study. Two pipelines by using DSI studio and FSL software were developed for data processing and ALPS index calculation. The ALPS index was obtained by the average of bilateral ALPS index and was used for testing the cross-vendor, inter-rater and test-retest reliability by using R studio software. The ALPS index demonstrated favorable inter-scanner reproducibility (ICC=0.77 to 0.95, P< 0.001), inter-rater reliability (ICC=0.96 to 1, P< 0.001) and test-retest repeatability (ICC=0.89 to 0.95, P< 0.001), offering a potential biomarker for in vivo evaluation of GS function.",

keywords = "Brain, Diffusion tensor image analysis along the perivascular space (DTI-ALPS), MarkVCID consortium, Neurofluids, glymphatic system",

author = "Xiaodan Liu and Giuseppe Barisano and Xingfeng Shao and Kay Jann and Ringman, {John M.} and Hanzhang Lu and Konstantinos Arfanakis and Arvind Caprihan and Charles DeCarli and Gold, {Brian T.} and Pauline Maillard and Satizabal, {Claudia L.} and Elyas Fadaee and Mohamad Habes and Lara Stables and Herpreet Singh and Bruce Fischl and {van der Kouwe}, Andre and Kristin Schwab and Helmer, {Karl G.} and Greenberg, {Steven M.} and Wang, {Danny J.J.}",

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language = "English",

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AU - Liu, Xiaodan

AU - Barisano, Giuseppe

AU - Shao, Xingfeng

AU - Jann, Kay

AU - Ringman, John M.

AU - Lu, Hanzhang

AU - Arfanakis, Konstantinos

AU - Caprihan, Arvind

AU - DeCarli, Charles

AU - Gold, Brian T.

AU - Maillard, Pauline

AU - Satizabal, Claudia L.

AU - Fadaee, Elyas

AU - Habes, Mohamad

AU - Stables, Lara

AU - Singh, Herpreet

AU - Fischl, Bruce

AU - van der Kouwe, Andre

AU - Schwab, Kristin

AU - Helmer, Karl G.

AU - Greenberg, Steven M.

AU - Wang, Danny J.J.

PY - 2024/8/1

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N2 - The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from the MarkVCID consortium were included in this study. Two pipelines by using DSI studio and FSL software were developed for data processing and ALPS index calculation. The ALPS index was obtained by the average of bilateral ALPS index and was used for testing the cross-vendor, inter-rater and test-retest reliability by using R studio software. The ALPS index demonstrated favorable inter-scanner reproducibility (ICC=0.77 to 0.95, P< 0.001), inter-rater reliability (ICC=0.96 to 1, P< 0.001) and test-retest repeatability (ICC=0.89 to 0.95, P< 0.001), offering a potential biomarker for in vivo evaluation of GS function.

AB - The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from the MarkVCID consortium were included in this study. Two pipelines by using DSI studio and FSL software were developed for data processing and ALPS index calculation. The ALPS index was obtained by the average of bilateral ALPS index and was used for testing the cross-vendor, inter-rater and test-retest reliability by using R studio software. The ALPS index demonstrated favorable inter-scanner reproducibility (ICC=0.77 to 0.95, P< 0.001), inter-rater reliability (ICC=0.96 to 1, P< 0.001) and test-retest repeatability (ICC=0.89 to 0.95, P< 0.001), offering a potential biomarker for in vivo evaluation of GS function.

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Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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