TY - JOUR
T1 - Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function
AU - Liu, Xiaodan
AU - Barisano, Giuseppe
AU - Shao, Xingfeng
AU - Jann, Kay
AU - Ringman, John M.
AU - Lu, Hanzhang
AU - Arfanakis, Konstantinos
AU - Caprihan, Arvind
AU - DeCarli, Charles
AU - Gold, Brian T.
AU - Maillard, Pauline
AU - Satizabal, Claudia L.
AU - Fadaee, Elyas
AU - Habes, Mohamad
AU - Stables, Lara
AU - Singh, Herpreet
AU - Fischl, Bruce
AU - van der Kouwe, Andre
AU - Schwab, Kristin
AU - Helmer, Karl G.
AU - Greenberg, Steven M.
AU - Wang, Danny J.J.
N1 - Publisher Copyright:
Copyright: © 2023 Liu X. et al.
PY - 2024/8/1
Y1 - 2024/8/1
N2 - The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from the MarkVCID consortium were included in this study. Two pipelines by using DSI studio and FSL software were developed for data processing and ALPS index calculation. The ALPS index was obtained by the average of bilateral ALPS index and was used for testing the cross-vendor, inter-rater and test-retest reliability by using R studio software. The ALPS index demonstrated favorable inter-scanner reproducibility (ICC=0.77 to 0.95, P< 0.001), inter-rater reliability (ICC=0.96 to 1, P< 0.001) and test-retest repeatability (ICC=0.89 to 0.95, P< 0.001), offering a potential biomarker for in vivo evaluation of GS function.
AB - The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from the MarkVCID consortium were included in this study. Two pipelines by using DSI studio and FSL software were developed for data processing and ALPS index calculation. The ALPS index was obtained by the average of bilateral ALPS index and was used for testing the cross-vendor, inter-rater and test-retest reliability by using R studio software. The ALPS index demonstrated favorable inter-scanner reproducibility (ICC=0.77 to 0.95, P< 0.001), inter-rater reliability (ICC=0.96 to 1, P< 0.001) and test-retest repeatability (ICC=0.89 to 0.95, P< 0.001), offering a potential biomarker for in vivo evaluation of GS function.
KW - Brain
KW - Diffusion tensor image analysis along the perivascular space (DTI-ALPS)
KW - MarkVCID consortium
KW - Neurofluids
KW - glymphatic system
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U2 - 10.14336/AD.2023.0321-2
DO - 10.14336/AD.2023.0321-2
M3 - Article
AN - SCOPUS:85200214947
VL - 15
SP - 1885
EP - 1898
JO - Aging and Disease
JF - Aging and Disease
IS - 4
ER -