CRP and neutrophils: Functional effects and complex uptake

E. G. Shephard, R. Anderson, A. F. Strachan, S. H. Kühn, F. C. De Beer

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.

Original languageEnglish
Pages (from-to)718-727
Number of pages10
JournalClinical and Experimental Immunology
Issue number3
StatePublished - 1986

Bibliographical note

Funding Information:
Supported in part by grants from the National Institute of Arthritis and Metabolic Diseases and the National Science Foundation. 2H . Bran£ and F. Chytil, Folia Microbiol (Prague) 11, 43 (1965). D, Monard, J. Jane~ek, and H. ¥. Rickenberg, Biochem. Biophys. Res. Commun. 35, 584 (1969).

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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