CRP and neutrophils: Functional effects and complex uptake

E. G. Shephard; R. Anderson; A. F. Strachan; S. H. Kühn; F. C. De Beer

CRP and neutrophils: Functional effects and complex uptake

E. G. Shephard, R. Anderson, A. F. Strachan, S. H. Kühn, F. C. De Beer

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Abstract

The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.

Original language	English
Pages (from-to)	718-727
Number of pages	10
Journal	Clinical and Experimental Immunology
Volume	63
Issue number	3
State	Published - 1986

Bibliographical note

Funding Information:
Supported in part by grants from the National Institute of Arthritis and Metabolic Diseases and the National Science Foundation. 2H . Bran£ and F. Chytil, Folia Microbiol (Prague) 11, 43 (1965). D, Monard, J. Jane~ek, and H. ¥. Rickenberg, Biochem. Biophys. Res. Commun. 35, 584 (1969).

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "CRP and neutrophils: Functional effects and complex uptake",

abstract = "The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.",

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note = "Funding Information: Supported in part by grants from the National Institute of Arthritis and Metabolic Diseases and the National Science Foundation. 2H . Bran£ and F. Chytil, Folia Microbiol (Prague) 11, 43 (1965). D, Monard, J. Jane~ek, and H. ¥. Rickenberg, Biochem. Biophys. Res. Commun. 35, 584 (1969).",

year = "1986",

language = "English",

volume = "63",

pages = "718--727",

number = "3",

}

TY - JOUR

T1 - CRP and neutrophils

T2 - Functional effects and complex uptake

AU - Shephard, E. G.

AU - Anderson, R.

AU - Strachan, A. F.

AU - Kühn, S. H.

AU - De Beer, F. C.

N1 - Funding Information: Supported in part by grants from the National Institute of Arthritis and Metabolic Diseases and the National Science Foundation. 2H . Bran£ and F. Chytil, Folia Microbiol (Prague) 11, 43 (1965). D, Monard, J. Jane~ek, and H. ¥. Rickenberg, Biochem. Biophys. Res. Commun. 35, 584 (1969).

PY - 1986

Y1 - 1986

N2 - The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.

AB - The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.

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M3 - Article

C2 - 3708910

AN - SCOPUS:0022616165

SN - 0009-9104

VL - 63

SP - 718

EP - 727

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 3

ER -

CRP and neutrophils: Functional effects and complex uptake

Abstract

Bibliographical note

ASJC Scopus subject areas

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