Crystallization of the Aα subunit of protein phosphatase 2A

M. O. Skidmore, M. R. Sawaya, S. Parkin, B. Rupp, H. Hope, S. J. Everse, G. Walter

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The Aα subunit of human protein phosphatase 2A forms crystals in space group P21 with cell dimensions a = 104.0, b = 174.9, c = 168.2 Å, and β angle = 90.2°. At cryogenic temperatures, the crystals diffracted to a resolution limit of ~3.0 Å. Based on the unit cell dimensions and a calculated molecular mass of 65,277 Da, the Matthews coefficient suggests eight molecules per asymmetric unit. Two native data sets were collected to a nominal resolution of 3.0 Å and merged to provide a set that is 93% complete, with R(sym) of 9.9%.

Original languageEnglish
Pages (from-to)1198-1200
Number of pages3
JournalProtein Science
Volume5
Issue number6
DOIs
StatePublished - 1996

Funding

FundersFunder number
National Institute of Diabetes and Digestive and Kidney DiseasesT32DK007233

    Keywords

    • X-ray crystallography
    • cryocooling
    • crystallization
    • protein phosphatase 2A

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

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