Cultures of equine respiratory epithelial cells and organ explants as tools for the study of equine influenza virus infection

C. Lin, R. E. Holland, N. M. Williams, T. M. Chambers

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Equine nasal turbinate epithelial cells and tracheal rafts were maintained with sustained viability in culture. Both types of culture supported productive replication of equine influenza virus (equine-2, subtype H3N8) and cell death occurred through apoptosis following viral infection. Thus, primary respiratory epithelial cell and organ cultures of equine origin may be valuable as alternatives to the intact animal for studying the virus-host interaction of equine respiratory viruses including influenza.

Original languageEnglish
Pages (from-to)2239-2247
Number of pages9
JournalArchives of Virology
Volume146
Issue number11
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Virology

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