Curbing cancer's sweet tooth: Is there a role for MnSOD in regulation of the Warburg effect?

Aaron K. Holley, Sanjit Kumar Dhar, Daret K. St. Clair

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect. The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future.

Original languageEnglish
Pages (from-to)170-188
Number of pages19
JournalMitochondrion
Volume13
Issue number3
DOIs
StatePublished - May 2013

Keywords

  • Cancer
  • Manganese superoxide dismutase
  • Mitochondria
  • Reactive oxygen species
  • Warburg effect

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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