TY - JOUR
T1 - Curbing cancer's sweet tooth
T2 - Is there a role for MnSOD in regulation of the Warburg effect?
AU - Holley, Aaron K.
AU - Dhar, Sanjit Kumar
AU - St. Clair, Daret K.
PY - 2013/5
Y1 - 2013/5
N2 - Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect. The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future.
AB - Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect. The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future.
KW - Cancer
KW - Manganese superoxide dismutase
KW - Mitochondria
KW - Reactive oxygen species
KW - Warburg effect
UR - http://www.scopus.com/inward/record.url?scp=84883751942&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883751942&partnerID=8YFLogxK
U2 - 10.1016/j.mito.2012.07.104
DO - 10.1016/j.mito.2012.07.104
M3 - Review article
C2 - 22820117
AN - SCOPUS:84883751942
SN - 1567-7249
VL - 13
SP - 170
EP - 188
JO - Mitochondrion
JF - Mitochondrion
IS - 3
ER -
