Curbing cancer's sweet tooth: Is there a role for MnSOD in regulation of the Warburg effect?

Aaron K. Holley; Sanjit Kumar Dhar; Daret K. St. Clair

doi:10.1016/j.mito.2012.07.104

Curbing cancer's sweet tooth: Is there a role for MnSOD in regulation of the Warburg effect?

Aaron K. Holley, Sanjit Kumar Dhar, Daret K. St. Clair

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect. The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future.

Original language	English
Pages (from-to)	170-188
Number of pages	19
Journal	Mitochondrion
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.mito.2012.07.104
State	Published - May 2013

Keywords

Cancer
Manganese superoxide dismutase
Mitochondria
Reactive oxygen species
Warburg effect

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mito.2012.07.104

Cite this

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title = "Curbing cancer's sweet tooth: Is there a role for MnSOD in regulation of the Warburg effect?",

abstract = "Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect. The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future.",

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language = "English",

volume = "13",

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T2 - Is there a role for MnSOD in regulation of the Warburg effect?

AU - Holley, Aaron K.

AU - Dhar, Sanjit Kumar

AU - St. Clair, Daret K.

PY - 2013/5

Y1 - 2013/5

N2 - Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect. The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future.

AB - Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect. The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future.

KW - Cancer

KW - Manganese superoxide dismutase

KW - Mitochondria

KW - Reactive oxygen species

KW - Warburg effect

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Curbing cancer's sweet tooth: Is there a role for MnSOD in regulation of the Warburg effect?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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