Curcumin Acrylation for Biological and Environmental Applications

Vinod S. Patil, Angela M. Gutierrez, Manjula Sunkara, Andrew J. Morris, J. Zach Hilt, Douglass S. Kalika, Thomas D. Dziubla

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Curcumin has recently gained interest for use in drug delivery, chemical sensing, and environmental applications. As a result, the development of synthesis strategies for the incorporation of curcumin into novel materials has become a priority. One such strategy, curcumin acrylation, involves the introduction of acrylate functional groups to the curcumin scaffold, with the potential generation of mono-, di-, and triacrylate curcumin species. The relative populations of these species in the resulting multiacrylate mixture can be controlled by the ratio of curcumin to acryloyl chloride in the initial reaction formulation. Characterization of the acrylation reaction and the resulting curcumin multiacrylate product is essential for the effective preparation of new curcumin-containing materials. In this work, a synthesis method for curcumin acrylation is presented and the resulting curcumin multiacrylate product is characterized via various techniques, i.e., HPLC, LCMS, and NMR, as a basis to establish the relationship between synthesis conditions and the extent of acrylation that is achieved.

Original languageEnglish
Pages (from-to)1964-1971
Number of pages8
JournalJournal of Natural Products
Issue number7
StatePublished - Jul 28 2017

Bibliographical note

Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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