Current and emerging clinical applications of multispectral optoacoustic tomography (MSOT) in oncology

Lacey R. McNally, Megan Mezera, Desiree E. Morgan, Peter J. Frederick, Eddy S. Yang, Isam Eldin Eltoum, William E. Grizzle

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Accurate detection and characterization of cancers are key for providing timely intervention and effective treatments. Current imaging technologies are particularly limited when it comes to detecting very small tumors in vivo, i.e., very early cancers or metastases, differentiating viable tumor from surrounding dead tumor tissue, and evaluating tumor metabolism within tissue. Optoacoustic imaging offers potential solutions to these imaging problems because of its ability to image optical absorption properties of both intrinsic tissue chromophores and exogenous contrast agents without the involvement of ionizing radiation. Optoacoustic imaging uses pulsed laser to induce localized thermoelastic expansion that generates acoustic waves detectable by an ultrasound transducer. To date, multispectral optoacoustic tomography (MSOT) has primarily been used in preclinical research; however, its use in translational and clinical research is expanding. This review focuses on current and emerging applications of optoacoustic imaging for molecular imaging of cancer using both exogenous and endogenous contrast agents and sheds light on potential future clinical applications.

Original languageEnglish
Pages (from-to)3432-3439
Number of pages8
JournalClinical Cancer Research
Issue number14
StatePublished - Jul 15 2016

Bibliographical note

Publisher Copyright:
©2016 American Association for Cancer Research.

ASJC Scopus subject areas

  • General Medicine


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