Current and emerging uses of statins in clinical therapeutics: A review

Jonathan T. Davies, Spencer F. Delfino, Chad E. Feinberg, Meghan F. Johnson, Veronica L. Nappi, Joshua T. Olinger, Anthony P. Schwab, Hollie I. Swanson

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

Statins, a class of cholesterol-lowering medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, are commonly administered to treat atherosclerotic cardiovascular disease. Statin use may expand considerably given its potential for treating an array of cholesterolindependent diseases. However, the lack of conclusive evidence supporting these emerging therapeutic uses of statins brings to the fore a number of unanswered questions including uncertainties regarding patient-to-patient variability in response to statins, the most appropriate statin to be used for the desired effect, and the efficacy of statins in treating cholesterol-independent diseases. In this review, the adverse effects, costs, and drug-drug and drug-food interactions associated with statin use are presented. Furthermore, we discuss the pleiotropic effects associated with statins with regard to the onset and progression of autoimmune and inflammatory diseases, cancer, neurodegenerative disorders, strokes, bacterial infections, and human immunodeficiency virus. Understanding these issues will improve the prognosis of patients who are administered statins and potentially expand our ability to treat a wide variety of diseases.

Original languageEnglish
Pages (from-to)13-29
Number of pages17
JournalLipid Insights
Volume9
Issue number1
DOIs
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© the authors, publisher and licensee Libertas Academica Limited.

Keywords

  • Adverse effects
  • Atherosclerotic cardiovascular disease
  • Autoimmune and chronic inflammatory diseases
  • Cancer
  • Low-density lipoprotein cholesterol
  • Statins

ASJC Scopus subject areas

  • Biochemistry

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