Current challenges and solutions in research and clinical care of older persons living with HIV: Findings presented at the 9th international workshop on HIV and aging

Erin E. Sundermann, Kristine M. Erlandson, Caitlin N. Pope, Anna Rubtsova, Jessica Montoya, Alison A. Moore, Catia Marzolini, Kelly K. O'Brien, Savita Pahwa, Brendan A.I. Payne, Leah H. Rubin, Sharon Walmsley, Norman J. Haughey, Monty Montano, Maile Y. Karris, Joseph B. Margolick, David J. Moore

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


In the era of effective antiretroviral therapy, the number of older people with HIV (PWH) is increasing, and those aging with HIV are experiencing an increasing burden of age-associated comorbidities. Life expectancy among older PWH is approaching that of demographically comparable HIV-uninfected (HIV-) adults. With this changing demographic of PWH come new challenges for researchers and clinicians in how to identify, address, and manage the complex interplay of treated HIV infection and aging-associated factors. In response to these challenges, the annual International Workshop on HIV and Aging was initiated in 2009 as a multidisciplinary platform for scientific discourse on the research and clinical complications arising from the aging population of PWH. The multidisciplinary nature of the workshop has resulted in a wide range of topics addressed over the past 9 years, from basic mechanisms in aging and HIV pathogenesis, to epidemiology of aging within large cohorts, interventions, and implementation of clinical programs. Herein, we summarize the key topics discussed at the 9th Annual International Workshop on HIV and Aging 2018, including "inflammaging," mitochondrial dysfunction, exercise interventions, HIV-associated neurocognitive impairment, metabolic dysfunction, menopause, and polypharmacy. In addition to recent developments in research and clinical care, we discuss open questions and future research directions required to better understand the interaction of HIV and aging.

Original languageEnglish
Pages (from-to)985-998
Number of pages14
JournalAIDS Research and Human Retroviruses
Issue number11-12
StatePublished - Nov 1 2019

Bibliographical note

Funding Information:
E.E.S., C.N.P., A.R., J.M., A.A.M, S.P., C.M., L.H.R, B.A.I.P., K.K.O., N.J.H., M.M., J.B.M., and D.J.M. have no conflicts of interest to declare. K.M.E. has received research funding from Gilead and Merck and has consultant fees from ViiV and Gilead. S.W. has received consultant fees, spoken at CME events, and received research funding from Gilead, Viiv, Jannsen, and Merck. M.Y.K. has received research funding to the institution from Gilead Sciences and ViiV Healthcare and consultant fees from Gilead.

Funding Information:
E.E.S.: RF1AG061070; M.M.: NIAID R01AI108541, NIA R21AG055415, Boston Pepper Center, P30 AG031679, HU CFAR P30 AI060354, Harvard University CFAR; J.L.M.: NIDA T32 DA031098 and NIMH R25 MH108389; K.M.E.: NIA K23 AG050260 and AG054366; D.J.M.: NIMH R01 MH099987 and U24 MH100928, and NIA RF1 AG061070; K.K.O.: Tier 2 Canada Research Chair in Episodic Disability and Rehabilitation (Canada Research Chairs Program). B.A.P.: Wellcome 109975/Z/15/Z, 203105/Z/16/Z; L.H.R.: NIMH R01 MH113512; C.M.: Swiss National Foundation 166204, OPO Foundation and Isaac Dreyfus Foundation; A.A.M.: P30 AG059299, and K24 AA15957; S.P.: NIAID, R01AI108472 and—AI123048 and CFAR grant P30 AI073961. M.Y.K.: NIA, R03AG060183 and P30 AG1036214.

Publisher Copyright:
© Copyright 2019, Mary Ann Liebert, Inc.


  • HIV
  • aging
  • comorbidities
  • inflammation
  • intervention
  • polypharmacy

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases


Dive into the research topics of 'Current challenges and solutions in research and clinical care of older persons living with HIV: Findings presented at the 9th international workshop on HIV and aging'. Together they form a unique fingerprint.

Cite this