TY - JOUR
T1 - Current development of saliva/oral fluid-based diagnostics.
AU - Yeh, Chih Ko
AU - Christodoulides, Nicolaos J.
AU - Floriano, Pierre N.
AU - Miller, Craig S.
AU - Ebersole, Jeffrey L.
AU - Weigum, Shannon E.
AU - McDevitt, John
AU - Redding, Spencer W.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2010/7
Y1 - 2010/7
N2 - Saliva can be easily obtained in medical and non-medical settings, and contains numerous bio-molecules, including those typically found in serum for disease detection and monitoring. In the past two decades, the achievements of high-throughput approaches afforded by biotechnology and nanotechnology allow for disease-specific salivary biomarker discovery and establishment of rapid, multiplex, and miniaturized analytical assays. These developments have dramatically advanced saliva-based diagnostics. In this review, we discuss the current consensus on development of saliva/oral fluid-based diagnostics and provide a summary of recent research advancements of the Texas-Kentucky Saliva Diagnostics Consortium. In the foreseeable future, current research on saliva based diagnostic methods could revolutionize health care.
AB - Saliva can be easily obtained in medical and non-medical settings, and contains numerous bio-molecules, including those typically found in serum for disease detection and monitoring. In the past two decades, the achievements of high-throughput approaches afforded by biotechnology and nanotechnology allow for disease-specific salivary biomarker discovery and establishment of rapid, multiplex, and miniaturized analytical assays. These developments have dramatically advanced saliva-based diagnostics. In this review, we discuss the current consensus on development of saliva/oral fluid-based diagnostics and provide a summary of recent research advancements of the Texas-Kentucky Saliva Diagnostics Consortium. In the foreseeable future, current research on saliva based diagnostic methods could revolutionize health care.
UR - https://www.scopus.com/pages/publications/79958031805
UR - https://www.scopus.com/pages/publications/79958031805#tab=citedBy
M3 - Review article
C2 - 20737986
AN - SCOPUS:79958031805
SN - 0040-4284
VL - 127
SP - 651
EP - 661
JO - Texas dental journal
JF - Texas dental journal
IS - 7
ER -