Current perspectives on saccharomyces cerevisiae sphingolipids

Robert C. Dickson; Robert L. Lester

doi:10.1007/4-431-34200-1_10

Current perspectives on saccharomyces cerevisiae sphingolipids

Robert C. Dickson, Robert L. Lester

Molecular and Cellular Biochemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

This review focuses on recent advances in our understanding of sphingolipid functions in Saccharomyces cerevisiae, particularly their role in signal transduction. The sphingoid long-chain bases, dihydrosphingosine and phytosphingosine, have gained prominence in yeast as regulators of the AGC-type protein kinase Pkh1 and Pkh2, homologs of mammalian phosphoinositide-dependent protein kinase 1 (PDK1). Pkh1 and Pkh2 activate the downstream kinases Pkc1, Ypk1, Ypk2 and Sch9. In addition, PHS acts downstream of Pkh1 and partially activates Ypk1, Ypk2 and Sch9. These kinases control a wide range of cellular processes including growth, cell wall integrity, stress resistance, endocytosis and aging. Our appreciation of long-chain bases as second messengers will grow as we learn more about the processes controlled by AGC kinases as well as other yeast kinases that are likely to be regulated by long-chain bases.

Original language	English
Title of host publication	Sphingolipid Biology
Pages	141-150
Number of pages	10
DOIs	https://doi.org/10.1007/4-431-34200-1_10
State	Published - 2006

Keywords

Pkh1
Pkh2
Saccharomyces cerevisiae
Sphingosine

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (all)

Access to Document

10.1007/4-431-34200-1_10

Cite this

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abstract = "This review focuses on recent advances in our understanding of sphingolipid functions in Saccharomyces cerevisiae, particularly their role in signal transduction. The sphingoid long-chain bases, dihydrosphingosine and phytosphingosine, have gained prominence in yeast as regulators of the AGC-type protein kinase Pkh1 and Pkh2, homologs of mammalian phosphoinositide-dependent protein kinase 1 (PDK1). Pkh1 and Pkh2 activate the downstream kinases Pkc1, Ypk1, Ypk2 and Sch9. In addition, PHS acts downstream of Pkh1 and partially activates Ypk1, Ypk2 and Sch9. These kinases control a wide range of cellular processes including growth, cell wall integrity, stress resistance, endocytosis and aging. Our appreciation of long-chain bases as second messengers will grow as we learn more about the processes controlled by AGC kinases as well as other yeast kinases that are likely to be regulated by long-chain bases.",

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AU - Lester, Robert L.

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Current perspectives on saccharomyces cerevisiae sphingolipids

Abstract

Keywords

ASJC Scopus subject areas

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