Cyclo-oxygenase-1-selective inhibitor SC-560

Sihui Long, Kathryn L. Theiss, Tonglei Li, Charles D. Loftin

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


In the title compound, 5-(4-chloro-phen-yl)-1-(4-methoxy-phen-yl)-3- (trifluoro-meth-yl)-1H-pyrazole (SC-560), C17H12ClF3N2O, a COX-1-selective inhibitor, the dihedral angles between the heterocycle and the chlorobenzene and methoxybenzene rings are 41.66 (6) and 43.08 (7)°, respectively. The dihedral angle between the two phenyl rings is 59.94 (6)°. No classic hydrogen bonds are possible in the crystal, and intermolecular interactions must be mainly of the dispersion type. This information may aid the identification of dosage formulations with improved oral bioavailability.

Original languageEnglish
Pages (from-to)o360
JournalActa Crystallographica Section E: Structure Reports Online
Issue number2
StatePublished - 2009

ASJC Scopus subject areas

  • Chemistry (all)
  • Materials Science (all)
  • Condensed Matter Physics


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