Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis

Robert Langenbach, Charles D. Loftin, Lee Christopher, Howard Tiano

Research output: Contribution to journalArticlepeer-review

139 Scopus citations

Abstract

Cyclooxygenase (COX)-1- and COX-2-deficient mice have unique physiological differences that have allowed investigation into the individual biological roles of the COX isoforms. In the following, the phenotypes of the two COX knockout mice are summarized, and recent studies to investigate the effects of COX deficiency on inflammatory responses and cancer susceptibility are discussed. The data suggest that both isoforms have important roles in the maintenance of physiological homeostasis and that such designations as housekeeping and/or response gene may not be entirely accurate. Furthermore, data from COX-deficient mice indicate that both isoforms can contribute to the inflammatory response and that both isoforms have significant roles in carcinogenesis.

Original languageEnglish
Pages (from-to)52-61
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume889
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Neuroscience (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • History and Philosophy of Science

Fingerprint

Dive into the research topics of 'Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis'. Together they form a unique fingerprint.

Cite this