Cyclooxygenase knockout mice Models for elucidating isoform-specific functions

Robert Langenbach, Charles Loftin, Christopher Lee, Howard Tiano

Research output: Contribution to journalArticlepeer-review

204 Scopus citations

Abstract

The development of cyclooxygenase (COX) deficient mice has allowed investigation into the individual physiological roles of the COX-1 and COX-2 isoforms. In the following article, the phenotypes of the two Ptgs (genes coding for COX-1 and COX-2) knockouts are summarized, and recent studies to investigate the effects of COX deficiency on cancer susceptibility, inflammatory response, gastric ulceration, and female reproductive processes are discussed. Also, the development and potential uses of mice deficient in both COX isoforms and mice containing only a single copy of one isoform are discussed. Additionally, when the data permit, the effects of genetic ablation of COX activity are compared with those of pharmacological inhibition of COX activity by nonsteroidal anti-inflammatory drugs. The data suggest that prostaglandins derived via the individual COX isoforms have separate as well as common functions. However, for the maintenance of normal physiology, it appears that deficiency of COX-2 has more profound effects than deficiency of COX-1. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1237-1246
Number of pages10
JournalBiochemical Pharmacology
Volume58
Issue number8
DOIs
StatePublished - Oct 15 1999

Keywords

  • Cancer
  • Cyclooxygenases
  • Gastric ulceration
  • Inflammation
  • Knockout
  • NSAIDs
  • Ptgs
  • Reproduction

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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