Cytoskeletal association of the cholera toxin receptor in rat erythrocytes

Naji Sahyoun, Talal Shatila, Harry Levine, Pedro Cuatrecasas

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Cholera toxin receptors are associated with the cytoskeletal residue of Triton X-100 extracts of rat erythrocytes. The solubilized cytoskeletal toxin-receptor complex appears to be a large macromolecular entity whose formation is facilitated by increased receptor occupancy. These findings suggest a role for GM1-gangliosides in transmembrane signalling and in the mechanism of action of cholera toxin.

Original languageEnglish
Pages (from-to)1216-1222
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Oct 30 1981

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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