Cytotoxic activities of new jadomycin derivatives

Jian Ting Zheng, Uwe Rix, Lixia Zhao, Cynthia Mattingly, Val Adams, Quan Chen, Jürgen Rohr, Ke Qian Yang

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Cytotoxic activities of jadomycin B and five new jadomycin derivatives against four cancer cell lines (HepG2, IM-9, IM-9/Bcl-2 and H460) were evaluated. Jadomycin S was most potent against HepG2, IM-9 and IM-9/Bcl-2 while jadomycin F was most potent against H460. Their potencies correlated with the degrees of apoptosis induced. Structure-activity-relationship analyses clearly demonstrate that the side chains of the oxazolone ring derived from the incorporated amino acids make a significant impact on biological activity. Therefore, jadomycin offers an ideal scaffold to manipulate structure and could be exploited to make many novel bioactive compounds with altered activities.

Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalJournal of Antibiotics
Issue number6
StatePublished - Jul 2005

Bibliographical note

Funding Information:
Acknowledgments We wish to thank Professor Xiu-Fen Kou for her assistance with purification methods, Mr. Li Xiao-Ming for his assistance with LC-MS analyses and Mrs. Wang Jing for her assistance operating flow cytometry. This work was supported by start-up funding from Institute of Microbiology and Chinese Academy of Sciences to KQY, and by the NIH and the Kentucky Lung Cancer Research Foundation to JR.


  • Cytotoxic
  • Derivative
  • Jadomycin
  • Streptomyces venezuelae

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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