Cytotoxicity of in vitro produced podophyllotoxin from Podophyllum hexandrum on human cancer cell line

Saurabh Chattopadhyay, V. S. Bisaria, A. K. Panda, A. K. Srivastava

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Podophyllotoxin was produced by cell culture of Podophyllum hexandrum under in vitro culture conditions. A maximum of 4.26 mg/L of podophyllotoxin was produced when P. hexandrum was cultivated in 3L stirred tank bioreactor. The compound extracted from the cell culture was applied to the human breast cancer cell line (MCF-7) and 1 nM podophyllotoxin was able to inhibit the growth of the cancer cells by 50%. The most profound inhibitory effect of podophyllotoxin was observed when it was applied in the beginning of cell growth.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalNatural Product Research
Volume18
Issue number1
DOIs
StatePublished - Feb 2004

Keywords

  • Human breast cancer cell line
  • MCF-7
  • Podophyllotoxin
  • Podophyllum hexandrum

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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