TY - JOUR
T1 - Cytotoxicity of in vitro produced podophyllotoxin from Podophyllum hexandrum on human cancer cell line
AU - Chattopadhyay, Saurabh
AU - Bisaria, V. S.
AU - Panda, A. K.
AU - Srivastava, A. K.
PY - 2004/2
Y1 - 2004/2
N2 - Podophyllotoxin was produced by cell culture of Podophyllum hexandrum under in vitro culture conditions. A maximum of 4.26 mg/L of podophyllotoxin was produced when P. hexandrum was cultivated in 3L stirred tank bioreactor. The compound extracted from the cell culture was applied to the human breast cancer cell line (MCF-7) and 1 nM podophyllotoxin was able to inhibit the growth of the cancer cells by 50%. The most profound inhibitory effect of podophyllotoxin was observed when it was applied in the beginning of cell growth.
AB - Podophyllotoxin was produced by cell culture of Podophyllum hexandrum under in vitro culture conditions. A maximum of 4.26 mg/L of podophyllotoxin was produced when P. hexandrum was cultivated in 3L stirred tank bioreactor. The compound extracted from the cell culture was applied to the human breast cancer cell line (MCF-7) and 1 nM podophyllotoxin was able to inhibit the growth of the cancer cells by 50%. The most profound inhibitory effect of podophyllotoxin was observed when it was applied in the beginning of cell growth.
KW - Human breast cancer cell line
KW - MCF-7
KW - Podophyllotoxin
KW - Podophyllum hexandrum
UR - http://www.scopus.com/inward/record.url?scp=0442309863&partnerID=8YFLogxK
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U2 - 10.1080/1057563031000122095
DO - 10.1080/1057563031000122095
M3 - Article
C2 - 14974618
AN - SCOPUS:0442309863
SN - 1478-6419
VL - 18
SP - 51
EP - 57
JO - Natural Product Research
JF - Natural Product Research
IS - 1
ER -
