Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment

William R. Markesber, Mark A. Lovell

Research output: Contribution to journalReview articlepeer-review

171 Scopus citations

Abstract

Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. Previous studies have shown oxidative damage to lipids, proteins, DNA, and RNA in multiple brain regions in late-stage Alzheimer disease. Recent studies on patients with amnestic mild cognitive impairment who have undergone autopsy have shown increased lipid peroxidation as well as protein, DNA, and RNA oxidation in multiple brain regions. These studies establish oxidative damage as an early event in the pathogenesis of Alzheimer disease that can serve as a therapeutic target to slow the progression or perhaps the onset of the disease.

Original languageEnglish
Pages (from-to)954-956
Number of pages3
JournalArchives of Neurology
Volume64
Issue number7
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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