TY - JOUR
T1 - Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment
AU - Markesber, William R.
AU - Lovell, Mark A.
PY - 2007/7
Y1 - 2007/7
N2 - Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. Previous studies have shown oxidative damage to lipids, proteins, DNA, and RNA in multiple brain regions in late-stage Alzheimer disease. Recent studies on patients with amnestic mild cognitive impairment who have undergone autopsy have shown increased lipid peroxidation as well as protein, DNA, and RNA oxidation in multiple brain regions. These studies establish oxidative damage as an early event in the pathogenesis of Alzheimer disease that can serve as a therapeutic target to slow the progression or perhaps the onset of the disease.
AB - Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. Previous studies have shown oxidative damage to lipids, proteins, DNA, and RNA in multiple brain regions in late-stage Alzheimer disease. Recent studies on patients with amnestic mild cognitive impairment who have undergone autopsy have shown increased lipid peroxidation as well as protein, DNA, and RNA oxidation in multiple brain regions. These studies establish oxidative damage as an early event in the pathogenesis of Alzheimer disease that can serve as a therapeutic target to slow the progression or perhaps the onset of the disease.
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U2 - 10.1001/archneur.64.7.954
DO - 10.1001/archneur.64.7.954
M3 - Review article
C2 - 17620484
AN - SCOPUS:34447279020
SN - 0003-9942
VL - 64
SP - 954
EP - 956
JO - Archives of Neurology
JF - Archives of Neurology
IS - 7
ER -