Data set for transcriptional response to depletion of the Shoc2 scaffolding protein

Eric C. Rouchka, Myoungkun Jeoung, Eun Ryoung Jang, Jinpeng Liu, Chi Wang, Xiaohong Li, Emilia Galperin

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3 Scopus citations


The Suppressor of Clear, Caenorhabditis elegans Homolog (SHOC2) is a scaffold protein that positively modulates activity of the RAS/ERK1/2 MAP kinase signaling cascade. We set out to understand the ERK1/2 pathway transcriptional response transduced through the SHOC2 scaffolding module. This data article describes raw gene expression within triplicates of kidney fibroblast-like Cos1 cell line expressing non-targeting shRNA (Cos-NT) and triplicates of Cos1 cells depleted of SHOC2 using shRNA (Cos-LV1) upon activation of ERK1/2 pathway by the Epidermal Growth Factor Receptor (EGFR). The data referred here is available in NCBI[U+05F3]s Gene Expression Omnibus (GEO), accession GEO: GSE67063 as well as NCBI[U+05F3]s Sequence Read Archive (SRA), accession SRA: SRP056324. A complete analysis of the results can be found in "Shoc2-tranduced ERK1/2 motility signals - Novel insights from functional genomics"(Jeoung et al., 2016) [1].

Original languageEnglish
Pages (from-to)770-778
Number of pages9
JournalData in Brief
StatePublished - Jun 1 2016

Bibliographical note

Funding Information:
The research was supported by NIH grants R00CA126161 (EG), R01GM113087 (EG), P20GM103486 (EG), P20GM103436 (XL and ECR) and the American Cancer Society (RSG-14-172-01-CSM, EG) . The article contents are solely the responsibility of the authors and do not represent the official views of the funding organizations, which were entirely uninvolved in the data generation or manuscript preparation.

Funding Information:
Core facility support was provided by the Genetic Technologies Core at the University of Kentucky (UK) Department of Molecular and Cellular Biochemistry (National Institutes of Health (NIH) Grant P20GM103486 ) and the UK Flow Cytometry and Cell Sorting Core Facility (funded by UK Office of the Vice President for Research, the Markey Cancer Center, and NIH grant R00CA177558 ).

Publisher Copyright:
© 2016 The Authors.

ASJC Scopus subject areas

  • General


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