Decoding the Hedgehog signal in animal development

J. Jia, J. Jiang

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


The Hedgehog (Hh) family of secreted proteins plays essential roles in a myriad of developmental processes via a complex signaling cascade conserved in species ranging from insects to mammals. In many developmental contexts, Hh acts as long-range morphogen to control distinct cellular outcomes as a function of its concentration. Here we review the current understanding of the Hh signaling mechanisms that govern the establishment of the Hh gradient and the transduction of the Hh signal with an emphasis on the intracellular signaling cascade from the receptor to the nuclear effector. We discuss how graded Hh signals are transduced to govern distinct developmental outcomes.

Original languageEnglish
Pages (from-to)1249-1265
Number of pages17
JournalCellular and Molecular Life Sciences
Issue number11
StatePublished - Jun 2006


  • Ci/Gli transcription factor
  • Development
  • Hedgehog signaling
  • Kinase
  • Patched
  • Pattern formation
  • Smoothened
  • Wnt

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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