Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

Jason Cook; Sumathi Krishnan; Subbian Ananth; Stephen F. Sells; Yang Shi; McClellan M. Walther; W. Marston Linehan; Vikas P. Sukhatme; Michael H. Weinstein; Vivek M. Rangnekar

doi:10.1038/sj.onc.1202416

Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

Jason Cook, Sumathi Krishnan, Subbian Ananth, Stephen F. Sells, Yang Shi, McClellan M. Walther, W. Marston Linehan, Vikas P. Sukhatme, Michael H. Weinstein, Vivek M. Rangnekar

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.

Original language	English
Pages (from-to)	1205-1208
Number of pages	4
Journal	Oncogene
Volume	18
Issue number	5
DOIs	https://doi.org/10.1038/sj.onc.1202416
State	Published - Feb 4 1999

Bibliographical note

Funding Information:
This work was supported by NIH grant CA60872 and Council for Tobacco Research-USA grant 3490 to VMR: NIH grant CA68258 to YS; and NIH grant DK44921 to VPS.

Keywords

Apoptosis
Par-4
Renal cell carcinoma

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.onc.1202416

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title = "Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma",

abstract = "Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.",

keywords = "Apoptosis, Par-4, Renal cell carcinoma",

author = "Jason Cook and Sumathi Krishnan and Subbian Ananth and Sells, {Stephen F.} and Yang Shi and Walther, {McClellan M.} and Linehan, {W. Marston} and Sukhatme, {Vikas P.} and Weinstein, {Michael H.} and Rangnekar, {Vivek M.}",

note = "Funding Information: This work was supported by NIH grant CA60872 and Council for Tobacco Research-USA grant 3490 to VMR: NIH grant CA68258 to YS; and NIH grant DK44921 to VPS.",

year = "1999",

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doi = "10.1038/sj.onc.1202416",

language = "English",

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AU - Cook, Jason

AU - Krishnan, Sumathi

AU - Ananth, Subbian

AU - Sells, Stephen F.

AU - Shi, Yang

AU - Walther, McClellan M.

AU - Linehan, W. Marston

AU - Sukhatme, Vikas P.

AU - Weinstein, Michael H.

AU - Rangnekar, Vivek M.

N1 - Funding Information: This work was supported by NIH grant CA60872 and Council for Tobacco Research-USA grant 3490 to VMR: NIH grant CA68258 to YS; and NIH grant DK44921 to VPS.

PY - 1999/2/4

Y1 - 1999/2/4

N2 - Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.

AB - Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.

KW - Apoptosis

KW - Par-4

KW - Renal cell carcinoma

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SN - 0950-9232

VL - 18

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JO - Oncogene

JF - Oncogene

IS - 5

ER -

Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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