Abstract
Deep brain stimulation (DBS) is used to treat the motor symptoms of Parkinson's disease patients by stimulating the subthalamic nucleus. However, optimization of DBS is still needed since the performance of the neural electrodes is limited by the body's response to the implant. This review discusses the issues with DBS, such as placement of electrodes, foreign body response, and electrode degradation. The current solutions to these technical issues include modifications to electrode material, coatings, and geometry.
| Original language | English |
|---|---|
| Article number | e3179 |
| Journal | Biotechnology Progress |
| Volume | 37 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2021 |
Bibliographical note
Publisher Copyright:© 2021 American Institute of Chemical Engineers.
Funding
The authors would like to thank Dr. Kristen Labazzo and Dr. Li Cai for their comments. This review was submitted by Emily Kolaya as part of the requirements for a Masters in Engineering from the Department of Biomedical Engineering at The State University of New Jersey.
| Funders |
|---|
| Biomedical Engineering |
| The State University of New Jersey |
Keywords
- electrode coatings
- electrode materials
- inflammatory response
- neural electrodes
- Parkinson's disease
ASJC Scopus subject areas
- Biotechnology
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