Defining the age-dependent and tissue-specific circadian transcriptome in male mice

Christopher A Wolff; Miguel A Gutierrez-Monreal; Lingsong Meng; Xiping Zhang; Lauren G Douma; Hannah M Costello; Collin M Douglas; Elnaz Ebrahimi; Ann Pham; Aline C Oliveira; Chunhua Fu; Amy Nguyen; Bryan R Alava; Stuart J Hesketh; Andrew R Morris; Mehari M Endale; G Ryan Crislip; Kit-Yan Cheng; Elizabeth A Schroder; Brian P Delisle; Andrew J Bryant; Michelle L Gumz; Zhiguang Huo; Andrew C Liu; Karyn A Esser

doi:10.1016/j.celrep.2022.111982

Defining the age-dependent and tissue-specific circadian transcriptome in male mice

Christopher A Wolff, Miguel A Gutierrez-Monreal, Lingsong Meng, Xiping Zhang, Lauren G Douma, Hannah M Costello, Collin M Douglas, Elnaz Ebrahimi, Ann Pham, Aline C Oliveira, Chunhua Fu, Amy Nguyen, Bryan R Alava, Stuart J Hesketh, Andrew R Morris, Mehari M Endale, G Ryan Crislip, Kit-Yan Cheng, Elizabeth A Schroder, Brian P DelisleAndrew J Bryant, Michelle L Gumz, Zhiguang Huo, Andrew C Liu, Karyn A Esser

Research output: Contribution to journal › Article › peer-review

Abstract

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level, we profile the circadian transcriptome in the hypothalamus, lung, heart, kidney, skeletal muscle, and adrenal gland in three age groups. We find age-dependent and tissue-specific clock output changes. Aging reduces the number of rhythmically expressed genes (REGs), indicative of weakened circadian control. REGs are enriched for the hallmarks of aging, adding another dimension to our understanding of aging. Analyzing differential gene expression within a tissue at four different times of day identifies distinct clusters of differentially expressed genes (DEGs). Increased variability of gene expression across the day is a common feature of aged tissues. This analysis extends the landscape for understanding aging and highlights the impact of aging on circadian clock function and temporal changes in gene expression.

Original language	English
Pages (from-to)	111982
Journal	Cell Reports
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2022.111982
State	E-pub ahead of print - Jan 9 2023

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Wolff, C. A., Gutierrez-Monreal, M. A., Meng, L., Zhang, X., Douma, L. G., Costello, H. M., Douglas, C. M., Ebrahimi, E., Pham, A., Oliveira, A. C., Fu, C., Nguyen, A., Alava, B. R., Hesketh, S. J., Morris, A. R., Endale, M. M., Crislip, G. R., Cheng, K.-Y., Schroder, E. A., ... Esser, K. A. (2023). Defining the age-dependent and tissue-specific circadian transcriptome in male mice. Cell Reports, 42(1), 111982. Advance online publication. https://doi.org/10.1016/j.celrep.2022.111982

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title = "Defining the age-dependent and tissue-specific circadian transcriptome in male mice",

abstract = "Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level, we profile the circadian transcriptome in the hypothalamus, lung, heart, kidney, skeletal muscle, and adrenal gland in three age groups. We find age-dependent and tissue-specific clock output changes. Aging reduces the number of rhythmically expressed genes (REGs), indicative of weakened circadian control. REGs are enriched for the hallmarks of aging, adding another dimension to our understanding of aging. Analyzing differential gene expression within a tissue at four different times of day identifies distinct clusters of differentially expressed genes (DEGs). Increased variability of gene expression across the day is a common feature of aged tissues. This analysis extends the landscape for understanding aging and highlights the impact of aging on circadian clock function and temporal changes in gene expression.",

author = "Wolff, {Christopher A} and Gutierrez-Monreal, {Miguel A} and Lingsong Meng and Xiping Zhang and Douma, {Lauren G} and Costello, {Hannah M} and Douglas, {Collin M} and Elnaz Ebrahimi and Ann Pham and Oliveira, {Aline C} and Chunhua Fu and Amy Nguyen and Alava, {Bryan R} and Hesketh, {Stuart J} and Morris, {Andrew R} and Endale, {Mehari M} and Crislip, {G Ryan} and Kit-Yan Cheng and Schroder, {Elizabeth A} and Delisle, {Brian P} and Bryant, {Andrew J} and Gumz, {Michelle L} and Zhiguang Huo and Liu, {Andrew C} and Esser, {Karyn A}",

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Wolff, CA, Gutierrez-Monreal, MA, Meng, L, Zhang, X, Douma, LG, Costello, HM, Douglas, CM, Ebrahimi, E, Pham, A, Oliveira, AC, Fu, C, Nguyen, A, Alava, BR, Hesketh, SJ, Morris, AR, Endale, MM, Crislip, GR, Cheng, K-Y, Schroder, EA , Delisle, BP, Bryant, AJ, Gumz, ML, Huo, Z, Liu, AC & Esser, KA 2023, 'Defining the age-dependent and tissue-specific circadian transcriptome in male mice', Cell Reports, vol. 42, no. 1, pp. 111982. https://doi.org/10.1016/j.celrep.2022.111982

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T1 - Defining the age-dependent and tissue-specific circadian transcriptome in male mice

AU - Wolff, Christopher A

AU - Gutierrez-Monreal, Miguel A

AU - Meng, Lingsong

AU - Zhang, Xiping

AU - Douma, Lauren G

AU - Costello, Hannah M

AU - Douglas, Collin M

AU - Ebrahimi, Elnaz

AU - Pham, Ann

AU - Oliveira, Aline C

AU - Fu, Chunhua

AU - Nguyen, Amy

AU - Alava, Bryan R

AU - Hesketh, Stuart J

AU - Morris, Andrew R

AU - Endale, Mehari M

AU - Crislip, G Ryan

AU - Cheng, Kit-Yan

AU - Schroder, Elizabeth A

AU - Delisle, Brian P

AU - Bryant, Andrew J

AU - Gumz, Michelle L

AU - Huo, Zhiguang

AU - Liu, Andrew C

AU - Esser, Karyn A

PY - 2023/1/9

Y1 - 2023/1/9

N2 - Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level, we profile the circadian transcriptome in the hypothalamus, lung, heart, kidney, skeletal muscle, and adrenal gland in three age groups. We find age-dependent and tissue-specific clock output changes. Aging reduces the number of rhythmically expressed genes (REGs), indicative of weakened circadian control. REGs are enriched for the hallmarks of aging, adding another dimension to our understanding of aging. Analyzing differential gene expression within a tissue at four different times of day identifies distinct clusters of differentially expressed genes (DEGs). Increased variability of gene expression across the day is a common feature of aged tissues. This analysis extends the landscape for understanding aging and highlights the impact of aging on circadian clock function and temporal changes in gene expression.

AB - Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level, we profile the circadian transcriptome in the hypothalamus, lung, heart, kidney, skeletal muscle, and adrenal gland in three age groups. We find age-dependent and tissue-specific clock output changes. Aging reduces the number of rhythmically expressed genes (REGs), indicative of weakened circadian control. REGs are enriched for the hallmarks of aging, adding another dimension to our understanding of aging. Analyzing differential gene expression within a tissue at four different times of day identifies distinct clusters of differentially expressed genes (DEGs). Increased variability of gene expression across the day is a common feature of aged tissues. This analysis extends the landscape for understanding aging and highlights the impact of aging on circadian clock function and temporal changes in gene expression.

U2 - 10.1016/j.celrep.2022.111982

DO - 10.1016/j.celrep.2022.111982

M3 - Article

C2 - 36640301

SN - 2211-1247

VL - 42

SP - 111982

JO - Cell Reports

JF - Cell Reports

IS - 1

ER -

Defining the age-dependent and tissue-specific circadian transcriptome in male mice

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