Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy

Weiguo Lu, Gustavo H. Olivera, Quan Chen, Kenneth J. Ruchala, Jason Haimerl, Sanford L. Meeks, Katja M. Langen, Patrick A. Kupelian

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


The incorporation of daily images into the radiotherapy process leads to adaptive radiation therapy (ART), in which the treatment is evaluated periodically and the plan is adaptively modified for the remaining course of radiotherapy. Deformable registration between the planning image and the daily images is a key component of ART. In this paper, we report our researches on deformable registration between the planning kVCT and the daily MVCT image sets. The method is based on a fast intensity-based free-form deformable registration technique. Considering the noise and contrast resolution differences between the kVCT and the MVCT, an 'edge-preserving smoothing' is applied to the MVCT image prior to the deformable registration process. We retrospectively studied daily MVCT images from commercial TomoTherapy machines from different clinical centers. The data set includes five head-neck cases, one pelvis case, two lung cases and one prostate case. Each case has one kVCT image and 20-40 MVCT images. We registered the MVCT images with their corresponding kVCT image. The similarity measures and visual inspections of contour matches by physicians validated this technique. The applications of deformable registration in ART, including 'deformable dose accumulation', 'automatic re-contouring' and 'tumour growth/regression evaluation' throughout the course of radiotherapy are also studied.

Original languageEnglish
Article number015
Pages (from-to)4357-4374
Number of pages18
JournalPhysics in Medicine and Biology
Issue number17
StatePublished - Sep 7 2006

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy'. Together they form a unique fingerprint.

Cite this