Degradation of poly(β-amino ester) gels in alcohols through transesterification: Method to conjugate drugs to polymer matrices

Prachi Gupta, Caroline Lacerda, Vinod S. Patil, Dipti Biswal, Paritosh Wattamwar, J. Zach Hilt, Thomas D. Dziubla

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Poly(β amino ester) (PβAE) polymers have received growing attention in the literature, owing to their ease of synthesis, versatile co-monomer selection, and highly tunable degradation kinetics. As such, they have shown extensive potential in many biomedical applications as well. In this work, it is demonstrated for the first time that PβAE polymers containing primary and secondary amine groups can undergo degradation by primary alcohols via transesterification mechanism. While this work emphasizes an important aspect of solvent compatibility of these networks, it also represents an interesting, simple mechanism for post synthesis drug incorporation, with riboflavin conjugation being demonstrated as a model compound.

Original languageEnglish
Pages (from-to)2019-2026
Number of pages8
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume55
Issue number12
DOIs
StatePublished - Jun 15 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Keywords

  • biomaterials
  • drug delivery
  • gels
  • polymer drug conjugate

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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