Degradation of target protein in living cells by small-molecule proteolysis inducer

Dong Zhang, Sun Hee Baek, Abby Ho, Kyungbo Kim

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Ubiquitin-dependent proteolysis of cellular proteins is one of the major pathways to regulate protein function posttranslationally. Here we demonstrate a potentially general method of degrading any targeted proteins by the ubiquitin-dependent proteolysis in living cells, using small-molecule proteolysis inducer (SMPI).

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
StatePublished - Feb 9 2004

Bibliographical note

Funding Information:
We are grateful to the Division of Pharmaceutical Sciences (Univ. of Kentucky) for generous start-up fund and COBRE (NIH NCRR P20 RR15592) and the Kentucky Lung Cancer Research Program for financial support. We also thank Dr. Rohr for comments on the manuscript.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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