Delayed elevation of platelet activating factor in ischemic hippocampus

L. Creed Pettigrew; Jerome J. Meyer; Susan D. Craddock; Steven M. Butler; Hsin Hsiung Tai; Robert A. Yokel

doi:10.1016/0006-8993(95)00709-Y

Delayed elevation of platelet activating factor in ischemic hippocampus

L. Creed Pettigrew, Jerome J. Meyer, Susan D. Craddock, Steven M. Butler, Hsin Hsiung Tai, Robert A. Yokel

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) into the extracellular space of ischemic hippocampus. The thromboxane level peaked after 20 min of postischemic reperfusion, followed by a delayed PAF response 120 min later. We conclude that cerebral ischemia causes delayed elevation of PAF in the extracellular space, long after the immediate synthesis and release of thromboxane metabolites.

Original language	English
Pages (from-to)	243-247
Number of pages	5
Journal	Brain Research
Volume	691
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(95)00709-Y
State	Published - Sep 11 1995

Keywords

Cerebral Ischemia
Hippocampus
Microdialysis
Platelet activating factor
Thromboxane A

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(95)00709-Y

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abstract = "We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) into the extracellular space of ischemic hippocampus. The thromboxane level peaked after 20 min of postischemic reperfusion, followed by a delayed PAF response 120 min later. We conclude that cerebral ischemia causes delayed elevation of PAF in the extracellular space, long after the immediate synthesis and release of thromboxane metabolites.",

keywords = "Cerebral Ischemia, Hippocampus, Microdialysis, Platelet activating factor, Thromboxane A",

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AU - Pettigrew, L. Creed

AU - Meyer, Jerome J.

AU - Craddock, Susan D.

AU - Butler, Steven M.

AU - Tai, Hsin Hsiung

AU - Yokel, Robert A.

PY - 1995/9/11

Y1 - 1995/9/11

N2 - We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) into the extracellular space of ischemic hippocampus. The thromboxane level peaked after 20 min of postischemic reperfusion, followed by a delayed PAF response 120 min later. We conclude that cerebral ischemia causes delayed elevation of PAF in the extracellular space, long after the immediate synthesis and release of thromboxane metabolites.

AB - We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) into the extracellular space of ischemic hippocampus. The thromboxane level peaked after 20 min of postischemic reperfusion, followed by a delayed PAF response 120 min later. We conclude that cerebral ischemia causes delayed elevation of PAF in the extracellular space, long after the immediate synthesis and release of thromboxane metabolites.

KW - Cerebral Ischemia

KW - Hippocampus

KW - Microdialysis

KW - Platelet activating factor

KW - Thromboxane A

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ER -

Delayed elevation of platelet activating factor in ischemic hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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