Delayed elevation of platelet activating factor in ischemic hippocampus

L. Creed Pettigrew, Jerome J. Meyer, Susan D. Craddock, Steven M. Butler, Hsin Hsiung Tai, Robert A. Yokel

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) into the extracellular space of ischemic hippocampus. The thromboxane level peaked after 20 min of postischemic reperfusion, followed by a delayed PAF response 120 min later. We conclude that cerebral ischemia causes delayed elevation of PAF in the extracellular space, long after the immediate synthesis and release of thromboxane metabolites.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalBrain Research
Issue number1-2
StatePublished - Sep 11 1995


  • Cerebral Ischemia
  • Hippocampus
  • Microdialysis
  • Platelet activating factor
  • Thromboxane A

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


Dive into the research topics of 'Delayed elevation of platelet activating factor in ischemic hippocampus'. Together they form a unique fingerprint.

Cite this