Delineating the earliest steps of gilvocarcin biosynthesis: Role of GilP and GilQ in starter unit specificity

Micah D. Shepherd, Madan K. Kharel, Lili L. Zhu, Steven G. Van Lanen, Jürgen Rohr

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In vivo and in vitro investigations of GilP and GilQ, two acyltransferases encoded by the gilvocarcin gene cluster, show that GilQ confers unique starter unit specificity when catalyzing an early as well as rate limiting step of gilvocarcin biosynthesis.

Original languageEnglish
Pages (from-to)3851-3856
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number17
DOIs
StatePublished - Sep 7 2010

Funding

FundersFunder number
National Childhood Cancer Registry – National Cancer InstituteR01CA102102

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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