Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma

Samir P. Patel; Felicia M. Michael; Jenna L. Gollihue; W. Brad Hubbard; Patrick G. Sullivan; Alexander G. Rabchevsky

doi:10.1016/j.mito.2022.11.001

Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma

Samir P. Patel, Felicia M. Michael, Jenna L. Gollihue, W. Brad Hubbard, Patrick G. Sullivan, Alexander G. Rabchevsky

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Herein, we review evidence that targeting mitochondrial dysfunction with ‘mitoceuticals’ is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism. We further discuss control measures to ensure greatest potential for mitochondrial transfer, notably using erodible thermogelling hydrogels to deliver respiratory competent mitochondria to the injured spinal cord.

Original language	English
Pages (from-to)	10-14
Number of pages	5
Journal	Mitochondrion
Volume	68
DOIs	https://doi.org/10.1016/j.mito.2022.11.001
State	Published - Jan 2023

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

Keywords

Bioenergetics
Hydrogel
Metabolism
Mitochondria
Oxidative phosphorylation
Spinal cord
Transplantation

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cell Biology

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10.1016/j.mito.2022.11.001

Cite this

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title = "Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma",

abstract = "Herein, we review evidence that targeting mitochondrial dysfunction with {\textquoteleft}mitoceuticals{\textquoteright} is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism. We further discuss control measures to ensure greatest potential for mitochondrial transfer, notably using erodible thermogelling hydrogels to deliver respiratory competent mitochondria to the injured spinal cord.",

keywords = "Bioenergetics, Hydrogel, Metabolism, Mitochondria, Oxidative phosphorylation, Spinal cord, Transplantation",

author = "Patel, {Samir P.} and Michael, {Felicia M.} and Gollihue, {Jenna L.} and {Brad Hubbard}, W. and Sullivan, {Patrick G.} and Rabchevsky, {Alexander G.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2023",

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doi = "10.1016/j.mito.2022.11.001",

language = "English",

volume = "68",

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AU - Patel, Samir P.

AU - Michael, Felicia M.

AU - Gollihue, Jenna L.

AU - Brad Hubbard, W.

AU - Sullivan, Patrick G.

AU - Rabchevsky, Alexander G.

PY - 2023/1

Y1 - 2023/1

N2 - Herein, we review evidence that targeting mitochondrial dysfunction with ‘mitoceuticals’ is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism. We further discuss control measures to ensure greatest potential for mitochondrial transfer, notably using erodible thermogelling hydrogels to deliver respiratory competent mitochondria to the injured spinal cord.

AB - Herein, we review evidence that targeting mitochondrial dysfunction with ‘mitoceuticals’ is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism. We further discuss control measures to ensure greatest potential for mitochondrial transfer, notably using erodible thermogelling hydrogels to deliver respiratory competent mitochondria to the injured spinal cord.

KW - Bioenergetics

KW - Hydrogel

KW - Metabolism

KW - Mitochondria

KW - Oxidative phosphorylation

KW - Spinal cord

KW - Transplantation

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AN - SCOPUS:85141464120

SN - 1567-7249

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SP - 10

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JO - Mitochondrion

JF - Mitochondrion

ER -

Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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