Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma

Samir P. Patel, Felicia M. Michael, Jenna L. Gollihue, W. Brad Hubbard, Patrick G. Sullivan, Alexander G. Rabchevsky

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Herein, we review evidence that targeting mitochondrial dysfunction with ‘mitoceuticals’ is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism. We further discuss control measures to ensure greatest potential for mitochondrial transfer, notably using erodible thermogelling hydrogels to deliver respiratory competent mitochondria to the injured spinal cord.

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalMitochondrion
Volume68
DOIs
StatePublished - Jan 2023

Bibliographical note

Funding Information:
Financial Support: DoD W81XWH2010347 (AGR); and NIH R01 NS119337 (AGR & SPP); Spinal Cord & Brain Injury Research Center Chair #1 and #3 Endowments, University of Kentucky (AGR & PGS).

Publisher Copyright:
© 2022 The Author(s)

Keywords

  • Bioenergetics
  • Hydrogel
  • Metabolism
  • Mitochondria
  • Oxidative phosphorylation
  • Spinal cord
  • Transplantation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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