Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration

Piotr Rychahou, Farzin Haque, Yi Shu, Yekaterina Zaytseva, Heidi L. Weiss, Eun Y. Lee, William Mustain, Joseph Valentino, Peixuan Guo, B. Mark Evers

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

The majority of deaths from all cancers, including colorectal cancer (CRC), is a result of tumor metastasis to distant organs. To date, an effective and safe system capable of exclusively targeting metastatic cancers that have spread to distant organs or lymph nodes does not exist. Here, we constructed multifunctional RNA nanoparticles, derived from the three-way junction (3WJ) of bacteriophage phi29 motor pRNA, to target metastatic cancer cells in a clinically relevant mouse model of CRC metastasis. The RNA nanoparticles demonstrated metastatic tumor homing without accumulation in normal organ tissues surrounding metastatic tumors. The RNA nanoparticles simultaneously targeted CRC cancer cells in major sites of metastasis, such as liver, lymph nodes, and lung. Our results demonstrate the therapeutic potential of these RNA nanoparticles as a delivery system for the treatment of CRC metastasis.

Original languageEnglish
Pages (from-to)1108-1116
Number of pages9
JournalACS Nano
Volume9
Issue number2
DOIs
StatePublished - Feb 24 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

Keywords

  • RNA nanoparticle
  • RNA therapeutics
  • bacteriophage phi29
  • colorectal cancer
  • metastasis
  • nanobiotechnology

ASJC Scopus subject areas

  • General Materials Science
  • General Engineering
  • General Physics and Astronomy

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