Dendritic changes in Alzheimer's disease and factors that may underlie these changes

Brian H. Anderton, Linda Callahan, Paul Coleman, Peter Davies, Dorothy Flood, Gregory A. Jicha, Thomas Ohm, Charles Weaver

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


It seems likely that the Alzheimer disease (AD)-related dendritic changes addressed in this article are induced by two principally different processes. One process is linked to the plastic response associated with deafferentation, that is, long-lasting transneuronally induced regressive changes in dendritic geometry and structure. The other process is associated with severe alterations of the dendritic- and perikaryal cytoskeleton as seen in neurons with the neurofibrillary pathology of AD, that is, the formation of paired helical filaments formed by hyperphosphorylated microtubule- associated protein tau. As the development of dendritic and cytoskeletal abnormalities are at least mediated by alterations in signal transduction, this article also reviews changes in signal pathways in AD. We also discuss transgenic approaches developed to model and understand cytoskeletal abnormalities.

Original languageEnglish
Pages (from-to)595-609
Number of pages15
JournalProgress in Neurobiology
Issue number6
StatePublished - Aug 1 1998

Bibliographical note

Funding Information:
The work of P.D., C.W. and G.A.J. is supported by NIMH Grant No. MH38623 and NIA Grant No. 06803. T.G.O. is supported by SFB 507-C2 and Hertie Stiftung Grant Nos OH 48/4-2, OH 48/1-3.

ASJC Scopus subject areas

  • General Neuroscience


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