Dendrophen, a novel glycyrrhetyl amino acid from Dendronephthya hemprichi

Mohamed Shaaban, Khaled A. Shaaban, Howaida I. Abd-Alla, Atef G. Hanna, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Chemical investigation of the extract of Dendronephthya hemprichi, collected from the Red Sea, Egypt, delivered dendrophen (1), the first 3β-acetoxy-glycyrrhetyl amino acid conjugate obtained from nature. Additionally, a new polyhydroxy sterol, dendrotriol (2), together with cholesterol and hexitol were isolated. Chromatographic separation of the low-polarity components of the D. hemprichi extract afforded 4-oxo-pentanoic acid, 2-methyl-acrylic acid 2-diethylaminoethyl ester (3), juniper camphor (4), and 2-octadecanone. The structures of 1 and 2 were confirmed by 1D and 2D NMR studies and mass spectrometry.

Original languageEnglish
Pages (from-to)425-432
Number of pages8
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volume66
Issue number4
DOIs
StatePublished - Apr 2011

Bibliographical note

Funding Information:
The authors are deeply thankful to Dr. M. Abd-Elghany, Hurgada, for the identification of Dendronephthya himprichi, and Dr. M. S. Abdel-Aziz, Department of Microbial Chemistry, NRC, Cairo, for the determination of antimicrobial activities. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. We thank also Ms. F. Lissy for biological tests and Mr. A. Kohl for technical assistance. M. Shaaban thanks the German Academic Exchange Service (DAAD) for a short-term grant.

Keywords

  • Biological activity
  • Dendronephthya hemprichi
  • Dendrophen
  • Dendrotriol

ASJC Scopus subject areas

  • General Chemistry

Fingerprint

Dive into the research topics of 'Dendrophen, a novel glycyrrhetyl amino acid from Dendronephthya hemprichi'. Together they form a unique fingerprint.

Cite this