Abstract
Chemical investigation of the extract of Dendronephthya hemprichi, collected from the Red Sea, Egypt, delivered dendrophen (1), the first 3β-acetoxy-glycyrrhetyl amino acid conjugate obtained from nature. Additionally, a new polyhydroxy sterol, dendrotriol (2), together with cholesterol and hexitol were isolated. Chromatographic separation of the low-polarity components of the D. hemprichi extract afforded 4-oxo-pentanoic acid, 2-methyl-acrylic acid 2-diethylaminoethyl ester (3), juniper camphor (4), and 2-octadecanone. The structures of 1 and 2 were confirmed by 1D and 2D NMR studies and mass spectrometry.
| Original language | English |
|---|---|
| Pages (from-to) | 425-432 |
| Number of pages | 8 |
| Journal | Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences |
| Volume | 66 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2011 |
Bibliographical note
Funding Information:The authors are deeply thankful to Dr. M. Abd-Elghany, Hurgada, for the identification of Dendronephthya himprichi, and Dr. M. S. Abdel-Aziz, Department of Microbial Chemistry, NRC, Cairo, for the determination of antimicrobial activities. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. We thank also Ms. F. Lissy for biological tests and Mr. A. Kohl for technical assistance. M. Shaaban thanks the German Academic Exchange Service (DAAD) for a short-term grant.
Keywords
- Biological activity
- Dendronephthya hemprichi
- Dendrophen
- Dendrotriol
ASJC Scopus subject areas
- Chemistry (all)