Depressive- and anxiety-like phenotypes in young adult APPSwe/PS1dE9 transgenic mice with insensitivity to chronic mild stress

Jun Ying Gao, Ying Chen, Dong Yuan Su, Charles Marshall, Ming Xiao

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Early Alzheimer's disease (AD) and depression share many symptoms, but the underlying mechanisms are not clear. Therefore, characterizing the shared and different biological changes between the two disorders will be helpful in making an early diagnosis and planning treatment. In the present study, 8-week-old APPSwe/PS1dE9 transgenic mice received chronic mild stress (CMS) for 8 weeks followed by a series of behavioral, biochemical and pathological analyses. APPSwe/PS1dE9 mice showed depressive- and anxiety-like behaviors, and reduced sociability, accompanied by high levels of soluble beta-amyloid, glial activation, neuroinflammation and brain derived neurotrophic factor signaling disturbance in the hippocampus. Notably, APPSwe/PS1dE9 mice exposure to CMS partially aggravated anxiety-like states rather than depressive-like responses and sociability deficits, with further elevated hippocampal interleukin-6 and tumor necrosis factor-α levels. These results demonstrated that young adult APPSwe/PS1dE9 have depressive- and anxiety-like phenotypes that were resistant to CMS compared to wild-type mice. This finding may help to understand the pathogenic mechanism of psychiatric symptoms associated with early AD.

Original languageEnglish
Pages (from-to)114-123
Number of pages10
JournalBehavioural Brain Research
Volume353
DOIs
StatePublished - Nov 1 2018

Bibliographical note

Funding Information:
This work was supported by grants from the National Natural Science Foundation of China ( 81671070 and 81271210 ) and the Natural Science Foundation of Jiangsu Educational Department ( 14KJA320001 ).

Publisher Copyright:
© 2018

Keywords

  • /PS1 mice
  • APP
  • Alzheimer's disease
  • Amyloid beta
  • Anxiety
  • Depression
  • Hippocampus

ASJC Scopus subject areas

  • Behavioral Neuroscience

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