Depressive symptoms and inflammatory biomarkers in patients with heart failure

Rebecca L. Dekker; Debra K. Moser; Elizabeth G. Tovar; Misook L. Chung; Seongkum Heo; Jia Rong Wu; Sandra B. Dunbar; Susan J. Pressler; Terry A. Lennie

doi:10.1177/1474515113507508

Depressive symptoms and inflammatory biomarkers in patients with heart failure

Rebecca L. Dekker, Debra K. Moser, Elizabeth G. Tovar, Misook L. Chung, Seongkum Heo, Jia Rong Wu, Sandra B. Dunbar, Susan J. Pressler, Terry A. Lennie

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Aim: To determine which inflammatory biomarkers are independently associated with depressive symptoms in heart failure.

Methods and results: We analyzed data from 428 outpatients enrolled in a heart failure registry (32% female, 61 } 12 years, 48% New York Heart Association Class III/IV). Depressive symptoms were measured with the Beck Depression Inventory-II. Serum C-reactive protein (CRP), cytokines (interleukin 1 receptor antagonist, 2, 4, 6, 8, 10), tumor necrosis alpha, and soluble receptors sTNFR1 and sTNFR2 were measured with enzyme immunoassay. Multiple regressions were used to determine which biomarkers were associated with depressive symptoms controlling for demographics, heart failure severity, and clinical variables. Twenty-seven percent (n = 119) had depressive symptoms. CRP was related to depressive symptoms after controlling for age and gender, but no inflammatory biomarkers were associated with depressive symptoms after controlling for all variables in the model.

Background: Inflammation may be a link between depressive symptoms and outcomes in patients with heart failure. It is not clear whether inflammatory markers are independently related to depressive symptoms in this population.

Conclusions: There was no relationship between inflammatory biomarkers and depressive symptoms. Our findings, in combination with prior researchers', suggest there is not a robust relationship between depressive symptoms and individual biomarkers of inflammation in heart failure.

Original language	English
Pages (from-to)	444-450
Number of pages	7
Journal	European Journal of Cardiovascular Nursing
Volume	13
Issue number	5
DOIs	https://doi.org/10.1177/1474515113507508
State	Published - Oct 1 2014

Bibliographical note

Publisher Copyright:
© The European Society of Cardiology 2013.

Funding

This work was supported by the American Association of Critical Care Nurses Phillips Medical Research, the American Heart Association (post-doctoral fellowship), the National Institutes of Health, National Institute of Nursing Research (grant numbers K23 NR013480, R01 NR 008567, R01 NR 009280), the University of Kentucky General Clinical Research Center (M01RR02602), the University of Kentucky College of Nursing Center for Biobehavioral Research on Self-Management (NINR, P20 NR 010679), the Emory University General Clinical Research Center (M01RR039) and the Atlanta Veterans Medical Center.

Funders	Funder number
American Association of Critical Care Nurses Phillips Medical Research
Atlanta Veterans Administration Medical Center
Emory University General Clinical Research Center	M01RR039
University of Kentucky College of Nursing Center for Biobehavioral Research on Self-Management
University of Kentucky General Clinical Research Center	M01RR02602
National Institutes of Health (NIH)
National Institute of Nursing Research	K23 NR013480, P20 NR 010679, R01 NR 009280, R01 NR 008567
National Center for Research Resources	M01RR002602
American Heart Association

Keywords

Inflammation
cardiovascular
cytokines
depression
heart failure

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
MedicalSurgical
Advanced and Specialized Nursing

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10.1177/1474515113507508

Cite this

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title = "Depressive symptoms and inflammatory biomarkers in patients with heart failure",

abstract = "Aim: To determine which inflammatory biomarkers are independently associated with depressive symptoms in heart failure.Methods and results: We analyzed data from 428 outpatients enrolled in a heart failure registry (32% female, 61 } 12 years, 48% New York Heart Association Class III/IV). Depressive symptoms were measured with the Beck Depression Inventory-II. Serum C-reactive protein (CRP), cytokines (interleukin 1 receptor antagonist, 2, 4, 6, 8, 10), tumor necrosis alpha, and soluble receptors sTNFR1 and sTNFR2 were measured with enzyme immunoassay. Multiple regressions were used to determine which biomarkers were associated with depressive symptoms controlling for demographics, heart failure severity, and clinical variables. Twenty-seven percent (n = 119) had depressive symptoms. CRP was related to depressive symptoms after controlling for age and gender, but no inflammatory biomarkers were associated with depressive symptoms after controlling for all variables in the model.Background: Inflammation may be a link between depressive symptoms and outcomes in patients with heart failure. It is not clear whether inflammatory markers are independently related to depressive symptoms in this population.Conclusions: There was no relationship between inflammatory biomarkers and depressive symptoms. Our findings, in combination with prior researchers', suggest there is not a robust relationship between depressive symptoms and individual biomarkers of inflammation in heart failure.",

keywords = "Inflammation, cardiovascular, cytokines, depression, heart failure",

author = "Dekker, {Rebecca L.} and Moser, {Debra K.} and Tovar, {Elizabeth G.} and Chung, {Misook L.} and Seongkum Heo and Wu, {Jia Rong} and Dunbar, {Sandra B.} and Pressler, {Susan J.} and Lennie, {Terry A.}",

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AU - Moser, Debra K.

AU - Tovar, Elizabeth G.

AU - Chung, Misook L.

AU - Heo, Seongkum

AU - Wu, Jia Rong

AU - Dunbar, Sandra B.

AU - Pressler, Susan J.

AU - Lennie, Terry A.

N1 - Publisher Copyright: © The European Society of Cardiology 2013.

PY - 2014/10/1

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N2 - Aim: To determine which inflammatory biomarkers are independently associated with depressive symptoms in heart failure.Methods and results: We analyzed data from 428 outpatients enrolled in a heart failure registry (32% female, 61 } 12 years, 48% New York Heart Association Class III/IV). Depressive symptoms were measured with the Beck Depression Inventory-II. Serum C-reactive protein (CRP), cytokines (interleukin 1 receptor antagonist, 2, 4, 6, 8, 10), tumor necrosis alpha, and soluble receptors sTNFR1 and sTNFR2 were measured with enzyme immunoassay. Multiple regressions were used to determine which biomarkers were associated with depressive symptoms controlling for demographics, heart failure severity, and clinical variables. Twenty-seven percent (n = 119) had depressive symptoms. CRP was related to depressive symptoms after controlling for age and gender, but no inflammatory biomarkers were associated with depressive symptoms after controlling for all variables in the model.Background: Inflammation may be a link between depressive symptoms and outcomes in patients with heart failure. It is not clear whether inflammatory markers are independently related to depressive symptoms in this population.Conclusions: There was no relationship between inflammatory biomarkers and depressive symptoms. Our findings, in combination with prior researchers', suggest there is not a robust relationship between depressive symptoms and individual biomarkers of inflammation in heart failure.

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Depressive symptoms and inflammatory biomarkers in patients with heart failure

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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