Depressive symptoms: Mediator of event-free survival in patients with heart failure

Muna H. Hammash, Terry A. Lennie, Timothy Crawford, Seongkum Heo, Misook L. Chung, Martha J. Biddle, Rebecca Dekker, Jia Rong Wu, Mary Kay Rayens, Debra K. Moser

Research output: Contribution to journalArticlepeer-review

Abstract

Depressive symptoms and poor health perceptions are predictors of higher hospitalization and mortality rates (heart failure [HF]). However, the association between depressive symptoms and health perceptions as they affect event-free survival outcomes in patients with HF has not been studied. The purpose of this secondary analysis was to determine whether depressive symptoms mediate the relationship between health perceptions and event-free survival in patients with HF. A total of 458 HF patients (61.6 ± 12 years, 55% New York Heart Association Class III/ IV) responded to one-item health perception question and completed the Patient Health Questionnaire-9. Event-free survival data were collected for up to 4 years. Multiple regression and Cox proportional hazards regression analysis showed that depressive symptoms mediated the relationship between health perceptions and event-free survival. Decreasing depressive symptoms is essential to improve event-free survival in patients with HF.

Original languageEnglish
Pages (from-to)539-552
Number of pages14
JournalWestern Journal of Nursing Research
Volume39
Issue number4
DOIs
StatePublished - Apr 2017

Bibliographical note

Publisher Copyright:
© The Author(s) 2016.

Keywords

  • Depressive symptoms
  • Event-free survival
  • Health perceptions
  • Heart failure
  • Mediation

ASJC Scopus subject areas

  • General Nursing

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