TY - JOUR
T1 - Design of environment-sensitive supramolecular assemblies for intracellular drug delivery
T2 - Polymeric micelles that are responsive to intracellular pH change
AU - Bae, Younsoo
AU - Fukushima, Shigeto
AU - Harada, Atsushi
AU - Kataoka, Kazunori
PY - 2003/10/6
Y1 - 2003/10/6
N2 - Drug smuggling: Micelles made up of block copolymers and the anticancer drug adriamycin (ADR), which is linked to the polymer by a pH-sensitive linker, have been prepared (see picture). Treatment of cancer cells with the micelles shows that the micelles are transported into the cell by endocytosis, thus bypassing the cell-membrane transporters. In the cell, the decrease in pH value triggers the release of the ADR, which retains its cytotoxic effect. The released ADR fluoresces which allows its localization within the cells to be detected.
AB - Drug smuggling: Micelles made up of block copolymers and the anticancer drug adriamycin (ADR), which is linked to the polymer by a pH-sensitive linker, have been prepared (see picture). Treatment of cancer cells with the micelles shows that the micelles are transported into the cell by endocytosis, thus bypassing the cell-membrane transporters. In the cell, the decrease in pH value triggers the release of the ADR, which retains its cytotoxic effect. The released ADR fluoresces which allows its localization within the cells to be detected.
KW - Anticancer agents
KW - Micelles
KW - Polymers
KW - Self-assembly
KW - Supramolecular chemistry
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U2 - 10.1002/anie.200250653
DO - 10.1002/anie.200250653
M3 - Article
C2 - 14533151
AN - SCOPUS:0142119372
SN - 1433-7851
VL - 42
SP - 4640
EP - 4643
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 38
ER -