Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators

Fuying Li; Qingzhang Zhu; Yi Zhang; Ying Feng; Ying Leng; Ao Zhang

doi:10.1016/j.bmc.2010.04.038

Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators

Fuying Li
, Qingzhang Zhu
, Yi Zhang
, Ying Feng
, Ying Leng
, Ao Zhang

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3875-3884
Number of pages	10
Journal	Bioorganic and Medicinal Chemistry
Volume	18
Issue number	11
DOIs	https://doi.org/10.1016/j.bmc.2010.04.038
State	Published - Jun 1 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aminothiazole
Arylacetamide
Glucokinase activator
Type 2 diabetes (T2D)

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10.1016/j.bmc.2010.04.038

Cite this

@article{1dea9b8f64aa44f9bd73471bcc69144d,

title = "Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators",

keywords = "Aminothiazole, Arylacetamide, Glucokinase activator, Type 2 diabetes (T2D)",

author = "Fuying Li and Qingzhang Zhu and Yi Zhang and Ying Feng and Ying Leng and Ao Zhang",

year = "2010",

month = jun,

day = "1",

doi = "10.1016/j.bmc.2010.04.038",

language = "English",

volume = "18",

pages = "3875--3884",

number = "11",

}

Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators. / Li, Fuying; Zhu, Qingzhang; Zhang, Yi et al.
In: Bioorganic and Medicinal Chemistry, Vol. 18, No. 11, 01.06.2010, p. 3875-3884.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators

AU - Li, Fuying

AU - Zhu, Qingzhang

AU - Zhang, Yi

AU - Feng, Ying

AU - Leng, Ying

AU - Zhang, Ao

PY - 2010/6/1

Y1 - 2010/6/1

KW - Aminothiazole

KW - Arylacetamide

KW - Glucokinase activator

KW - Type 2 diabetes (T2D)

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elsevierpure&SrcAuth=WosAPI&KeyUT=WOS:000278078600028&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1016/j.bmc.2010.04.038

DO - 10.1016/j.bmc.2010.04.038

M3 - Article

C2 - 20472448

SN - 0968-0896

VL - 18

SP - 3875

EP - 3884

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 11

ER -

Design, synthesis, and pharmacological evaluation of <i>N</i>-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2<i>H</i>-pyran-4-yl) propanamides as glucokinase activators

UN SDGs

Keywords

Access to Document

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