Destruction of a destructor: A new avenue for cancer therapeutics targeting the Wnt pathway

Chunming Liu; Xi He

doi:10.1093/jmcb/mjp040

Destruction of a destructor: A new avenue for cancer therapeutics targeting the Wnt pathway

Chunming Liu, Xi He

Molecular and Cellular Biochemistry

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A new study in Nature has identified a small molecule inhibitor for the oncogenic Wnt/β-catenin pathway that is responsible for many human cancers. This inhibitor targets an unsuspected cellular enzyme, Tankyrase, which controls the destruction of a β-catenin destructor.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	Journal of Molecular Cell Biology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1093/jmcb/mjp040
State	Published - 2010

Funding

Funders	Funder number
National Institute of General Medical Sciences	R01GM074241

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jmcb/mjp040

Cite this

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title = "Destruction of a destructor: A new avenue for cancer therapeutics targeting the Wnt pathway",

abstract = "A new study in Nature has identified a small molecule inhibitor for the oncogenic Wnt/β-catenin pathway that is responsible for many human cancers. This inhibitor targets an unsuspected cellular enzyme, Tankyrase, which controls the destruction of a β-catenin destructor.",

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Destruction of a destructor: A new avenue for cancer therapeutics targeting the Wnt pathway

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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