Detection of Biofilm in Wounds as an Early Indicator for Risk for Tissue Infection and Wound Chronicity

Krishna S. Vyas, Lesley K. Wong

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Wounds are dynamic environments in which dead tissue, exudate, and the bacterial bioburden interact in a complex manner among themselves and with the tissue of the host. Bacteria organize into biofilms, reducing their susceptibility to elimination by the host immune response and antimicrobials. Early detection of biofilms in wounds is crucial to successful chronic wound management; and although many techniques have developed to identify planktonic counterparts in viable wounds, few have been able to quickly and accurately identify bacterial biofilms. Future studies are needed to find means of identifying and monitoring biofilm colonization at the bedside to permit timely initiation of treatment. In this review, we examine some promising new technologies that hope to identify and quantify the process of biofilm formation in chronic wounds.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalAnnals of Plastic Surgery
Volume76
Issue number1
DOIs
StatePublished - Jan 1 2016

Bibliographical note

Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc.

Keywords

  • biofilm
  • biofilm detection
  • biofilm matrix
  • chronic wound

ASJC Scopus subject areas

  • Surgery

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