Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes

K. M. Thrailkill; C. H. Jo; G. E. Cockrell; C. S. Moreau; C. K. Lumpkin; J. L. Fowlkes

doi:10.1007/s00198-011-1807-7

Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes

K. M. Thrailkill, C. H. Jo, G. E. Cockrell, C. S. Moreau, C. K. Lumpkin, J. L. Fowlkes

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Summary To determine whether undercarboxylated osteocalcin (UC-OC) or gamma-carboxyglutamic-carboxylated-type osteocalcin (GLA-OC) concentrations deviate from normal in type 1 diabetes (T1D), serum levels were compared between 115 subjects with T1D and 55 age-matched healthy controls. UC-OC and GLA-OC concentrations were similar between groups; however, in T1D, UC-OC correlated positively with markers of insulin exposure, either endogenously produced or exogenously administered. Introduction A study was conducted to determine whether dysregulation of circulating concentrations of UC-OC or GLA-OC occurs in patients with type 1 diabetes, a condition of insulin deficiency without insulin resistance. Methods We measured serum concentrations of UC-OC and GLA-OC in 115 subjects with T1D, ages 14-40 years, and in 55 age-matched healthy control subjects. Relationships between UC-OC and GLA-OC concentrations and patient characteristics (gender and age), indices of glycemic control (hemoglobin A1c (HbA1c), fasting plasma glucose, C-peptide concentration, 3-day average glucose measured by a continuous glucose sensor, total daily insulin dose) and circulating indices of skeletal homeostasis (total calcium, 25-OH vitamin D, parathyroid hormone, insulin-like growth factor 1 (IGF-1), type 1 collagen degradation fragments (CTX), adiponectin, leptin) were examined. Between group differences in the concentrations of UCOC and GLA-OC were the main outcome measures. Results Although adiponectin levels were higher in the T1D group, between-group comparisons did not reveal statistically significant differences in concentration of UCOC, GLA-OC, CTX or leptin between the T1D and control populations. Instead, by multivariate regression modeling, UC-OC was correlated with younger age (p<0.001), higher CTX (p<0.001), lower HbA1c (p=0.013), and higher IGF- 1 (p=0.086). Moreover, within the T1D subgroup, UC-OC was positively correlated with C-peptide/glucose ratio (reflecting endogenous insulin secretion), with IGF-1 (reflecting intra-portal insulin sufficiency), and with total daily insulin dose. Conclusions In T1D, UC-OC appears to correlate positively with markers of insulin exposure, either endogenously produced or exogenously administered.

Original language	English
Pages (from-to)	1799-1806
Number of pages	8
Journal	Osteoporosis International
Volume	23
Issue number	6
DOIs	https://doi.org/10.1007/s00198-011-1807-7
State	Published - Jun 2012

Bibliographical note

Funding Information:
This work was supported by grants from the National Institutes of Health to KMT (R01-DK62999); to the UAMS General Clinical Research Center (M01 RR14288) and to the Arkansas Children’s Hospital Research Institute (C06RR16517). Additional funding was provided by the Minnie Merrill Sturgis Diabetes Research Fund and the Arkansas Biosciences Institute. The authors are also grateful to the study subjects and their families for participation in this research.

Funding Information:
Grants from the National Institutes of Health to KMT (R01-DK62999), to the UAMS General Clinical Research Center (M01 RR14288) and to the Arkansas Children’s Hospital Research Institute (C06RR16517), as well as funds from the Minnie Merrill Sturgis Diabetes Research Fund and the Arkansas Biosciences Institute.

Keywords

Adiponectin
IGF-1
Insulin
Leptin
Osteoporosis

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00198-011-1807-7

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@article{891d4b076d42410cb6ba78ee03ca0f74,

title = "Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes",

abstract = "Summary To determine whether undercarboxylated osteocalcin (UC-OC) or gamma-carboxyglutamic-carboxylated-type osteocalcin (GLA-OC) concentrations deviate from normal in type 1 diabetes (T1D), serum levels were compared between 115 subjects with T1D and 55 age-matched healthy controls. UC-OC and GLA-OC concentrations were similar between groups; however, in T1D, UC-OC correlated positively with markers of insulin exposure, either endogenously produced or exogenously administered. Introduction A study was conducted to determine whether dysregulation of circulating concentrations of UC-OC or GLA-OC occurs in patients with type 1 diabetes, a condition of insulin deficiency without insulin resistance. Methods We measured serum concentrations of UC-OC and GLA-OC in 115 subjects with T1D, ages 14-40 years, and in 55 age-matched healthy control subjects. Relationships between UC-OC and GLA-OC concentrations and patient characteristics (gender and age), indices of glycemic control (hemoglobin A1c (HbA1c), fasting plasma glucose, C-peptide concentration, 3-day average glucose measured by a continuous glucose sensor, total daily insulin dose) and circulating indices of skeletal homeostasis (total calcium, 25-OH vitamin D, parathyroid hormone, insulin-like growth factor 1 (IGF-1), type 1 collagen degradation fragments (CTX), adiponectin, leptin) were examined. Between group differences in the concentrations of UCOC and GLA-OC were the main outcome measures. Results Although adiponectin levels were higher in the T1D group, between-group comparisons did not reveal statistically significant differences in concentration of UCOC, GLA-OC, CTX or leptin between the T1D and control populations. Instead, by multivariate regression modeling, UC-OC was correlated with younger age (p<0.001), higher CTX (p<0.001), lower HbA1c (p=0.013), and higher IGF- 1 (p=0.086). Moreover, within the T1D subgroup, UC-OC was positively correlated with C-peptide/glucose ratio (reflecting endogenous insulin secretion), with IGF-1 (reflecting intra-portal insulin sufficiency), and with total daily insulin dose. Conclusions In T1D, UC-OC appears to correlate positively with markers of insulin exposure, either endogenously produced or exogenously administered.",

keywords = "Adiponectin, IGF-1, Insulin, Leptin, Osteoporosis",

author = "Thrailkill, {K. M.} and Jo, {C. H.} and Cockrell, {G. E.} and Moreau, {C. S.} and Lumpkin, {C. K.} and Fowlkes, {J. L.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health to KMT (R01-DK62999); to the UAMS General Clinical Research Center (M01 RR14288) and to the Arkansas Children{\textquoteright}s Hospital Research Institute (C06RR16517). Additional funding was provided by the Minnie Merrill Sturgis Diabetes Research Fund and the Arkansas Biosciences Institute. The authors are also grateful to the study subjects and their families for participation in this research. Funding Information: Grants from the National Institutes of Health to KMT (R01-DK62999), to the UAMS General Clinical Research Center (M01 RR14288) and to the Arkansas Children{\textquoteright}s Hospital Research Institute (C06RR16517), as well as funds from the Minnie Merrill Sturgis Diabetes Research Fund and the Arkansas Biosciences Institute.",

year = "2012",

month = jun,

doi = "10.1007/s00198-011-1807-7",

language = "English",

volume = "23",

pages = "1799--1806",

number = "6",

}

TY - JOUR

T1 - Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes

AU - Thrailkill, K. M.

AU - Jo, C. H.

AU - Cockrell, G. E.

AU - Moreau, C. S.

AU - Lumpkin, C. K.

AU - Fowlkes, J. L.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health to KMT (R01-DK62999); to the UAMS General Clinical Research Center (M01 RR14288) and to the Arkansas Children’s Hospital Research Institute (C06RR16517). Additional funding was provided by the Minnie Merrill Sturgis Diabetes Research Fund and the Arkansas Biosciences Institute. The authors are also grateful to the study subjects and their families for participation in this research. Funding Information: Grants from the National Institutes of Health to KMT (R01-DK62999), to the UAMS General Clinical Research Center (M01 RR14288) and to the Arkansas Children’s Hospital Research Institute (C06RR16517), as well as funds from the Minnie Merrill Sturgis Diabetes Research Fund and the Arkansas Biosciences Institute.

PY - 2012/6

Y1 - 2012/6

N2 - Summary To determine whether undercarboxylated osteocalcin (UC-OC) or gamma-carboxyglutamic-carboxylated-type osteocalcin (GLA-OC) concentrations deviate from normal in type 1 diabetes (T1D), serum levels were compared between 115 subjects with T1D and 55 age-matched healthy controls. UC-OC and GLA-OC concentrations were similar between groups; however, in T1D, UC-OC correlated positively with markers of insulin exposure, either endogenously produced or exogenously administered. Introduction A study was conducted to determine whether dysregulation of circulating concentrations of UC-OC or GLA-OC occurs in patients with type 1 diabetes, a condition of insulin deficiency without insulin resistance. Methods We measured serum concentrations of UC-OC and GLA-OC in 115 subjects with T1D, ages 14-40 years, and in 55 age-matched healthy control subjects. Relationships between UC-OC and GLA-OC concentrations and patient characteristics (gender and age), indices of glycemic control (hemoglobin A1c (HbA1c), fasting plasma glucose, C-peptide concentration, 3-day average glucose measured by a continuous glucose sensor, total daily insulin dose) and circulating indices of skeletal homeostasis (total calcium, 25-OH vitamin D, parathyroid hormone, insulin-like growth factor 1 (IGF-1), type 1 collagen degradation fragments (CTX), adiponectin, leptin) were examined. Between group differences in the concentrations of UCOC and GLA-OC were the main outcome measures. Results Although adiponectin levels were higher in the T1D group, between-group comparisons did not reveal statistically significant differences in concentration of UCOC, GLA-OC, CTX or leptin between the T1D and control populations. Instead, by multivariate regression modeling, UC-OC was correlated with younger age (p<0.001), higher CTX (p<0.001), lower HbA1c (p=0.013), and higher IGF- 1 (p=0.086). Moreover, within the T1D subgroup, UC-OC was positively correlated with C-peptide/glucose ratio (reflecting endogenous insulin secretion), with IGF-1 (reflecting intra-portal insulin sufficiency), and with total daily insulin dose. Conclusions In T1D, UC-OC appears to correlate positively with markers of insulin exposure, either endogenously produced or exogenously administered.

AB - Summary To determine whether undercarboxylated osteocalcin (UC-OC) or gamma-carboxyglutamic-carboxylated-type osteocalcin (GLA-OC) concentrations deviate from normal in type 1 diabetes (T1D), serum levels were compared between 115 subjects with T1D and 55 age-matched healthy controls. UC-OC and GLA-OC concentrations were similar between groups; however, in T1D, UC-OC correlated positively with markers of insulin exposure, either endogenously produced or exogenously administered. Introduction A study was conducted to determine whether dysregulation of circulating concentrations of UC-OC or GLA-OC occurs in patients with type 1 diabetes, a condition of insulin deficiency without insulin resistance. Methods We measured serum concentrations of UC-OC and GLA-OC in 115 subjects with T1D, ages 14-40 years, and in 55 age-matched healthy control subjects. Relationships between UC-OC and GLA-OC concentrations and patient characteristics (gender and age), indices of glycemic control (hemoglobin A1c (HbA1c), fasting plasma glucose, C-peptide concentration, 3-day average glucose measured by a continuous glucose sensor, total daily insulin dose) and circulating indices of skeletal homeostasis (total calcium, 25-OH vitamin D, parathyroid hormone, insulin-like growth factor 1 (IGF-1), type 1 collagen degradation fragments (CTX), adiponectin, leptin) were examined. Between group differences in the concentrations of UCOC and GLA-OC were the main outcome measures. Results Although adiponectin levels were higher in the T1D group, between-group comparisons did not reveal statistically significant differences in concentration of UCOC, GLA-OC, CTX or leptin between the T1D and control populations. Instead, by multivariate regression modeling, UC-OC was correlated with younger age (p<0.001), higher CTX (p<0.001), lower HbA1c (p=0.013), and higher IGF- 1 (p=0.086). Moreover, within the T1D subgroup, UC-OC was positively correlated with C-peptide/glucose ratio (reflecting endogenous insulin secretion), with IGF-1 (reflecting intra-portal insulin sufficiency), and with total daily insulin dose. Conclusions In T1D, UC-OC appears to correlate positively with markers of insulin exposure, either endogenously produced or exogenously administered.

KW - Adiponectin

KW - IGF-1

KW - Insulin

KW - Leptin

KW - Osteoporosis

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Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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