Determination of the interday and intraday reliability of serum cartilage oligomeric matrix protein in a physically active population

Johanna M. Hoch; Carl G. Mattacola; Jennifer M. Medina-McKeon; Jay N. Shah; Christian Lattermann

doi:10.1177/1947603511414179

Determination of the interday and intraday reliability of serum cartilage oligomeric matrix protein in a physically active population

Johanna M. Hoch, Carl G. Mattacola, Jennifer M. Medina-McKeon, Jay N. Shah, Christian Lattermann

Athletic Training and Clinical Nutrition

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: To determine the intraday and interday reliability of serum cartilage oligomeric matrix protein (sCOMP) in a physically active population with no history of lower extremity surgery. Design: A repeated-measures reliability study was employed to determine the intraday and interday reliability of sCOMP in a physically active cohort. A total of 23 subjects were recruited to the laboratory on 3 separate occasions for nonfasting serum collection. Subjects had no history of lower extremity surgery and were free from acute injury within the last 3 months. Results: Our results indicate strong reliability for both intraday intraclass correlation coefficient (ICC) (0.76) and interday ICC (0.74) sCOMP values. Conclusion: Our results demonstrate that following 30 minutes of inactivity, nonfasting serum samples remain stable over the course of 1 day and between 2 consecutive days in a healthy population with no history of lower extremity surgery. Future research studies are needed to further investigate the magnitude of change in this biomarker for patients with acute articular cartilage damage to determine its appropriateness for use in this population and for varying degrees of articular cartilage severity.

Original language	English
Pages (from-to)	394-398
Number of pages	5
Journal	Cartilage
Volume	2
Issue number	4
DOIs	https://doi.org/10.1177/1947603511414179
State	Published - Oct 2011

Bibliographical note

Funding Information:
The authors thank the associate dean of research, College of Health Sciences, University of Kentucky, for funding their research through the College of Health Sciences Pilot Study Grant Mechanism. They also thank the University of Kentucky CR-DOC laboratory and Ken Westberry for completing the ELISAs. Finally, they thank Matthew R. Luckett, MD, for his assistance in collecting the serum samples. This research study was supported by the College of Health Sciences Pilot Study Grant Mechanism.

Keywords

Articular cartilage
Biomarkers
Knee injury

ASJC Scopus subject areas

General Medicine

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10.1177/1947603511414179

Cite this

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title = "Determination of the interday and intraday reliability of serum cartilage oligomeric matrix protein in a physically active population",

abstract = "Objective: To determine the intraday and interday reliability of serum cartilage oligomeric matrix protein (sCOMP) in a physically active population with no history of lower extremity surgery. Design: A repeated-measures reliability study was employed to determine the intraday and interday reliability of sCOMP in a physically active cohort. A total of 23 subjects were recruited to the laboratory on 3 separate occasions for nonfasting serum collection. Subjects had no history of lower extremity surgery and were free from acute injury within the last 3 months. Results: Our results indicate strong reliability for both intraday intraclass correlation coefficient (ICC) (0.76) and interday ICC (0.74) sCOMP values. Conclusion: Our results demonstrate that following 30 minutes of inactivity, nonfasting serum samples remain stable over the course of 1 day and between 2 consecutive days in a healthy population with no history of lower extremity surgery. Future research studies are needed to further investigate the magnitude of change in this biomarker for patients with acute articular cartilage damage to determine its appropriateness for use in this population and for varying degrees of articular cartilage severity.",

keywords = "Articular cartilage, Biomarkers, Knee injury",

author = "Hoch, {Johanna M.} and Mattacola, {Carl G.} and Medina-McKeon, {Jennifer M.} and Shah, {Jay N.} and Christian Lattermann",

note = "Funding Information: The authors thank the associate dean of research, College of Health Sciences, University of Kentucky, for funding their research through the College of Health Sciences Pilot Study Grant Mechanism. They also thank the University of Kentucky CR-DOC laboratory and Ken Westberry for completing the ELISAs. Finally, they thank Matthew R. Luckett, MD, for his assistance in collecting the serum samples. This research study was supported by the College of Health Sciences Pilot Study Grant Mechanism. ",

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doi = "10.1177/1947603511414179",

language = "English",

volume = "2",

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AU - Hoch, Johanna M.

AU - Mattacola, Carl G.

AU - Medina-McKeon, Jennifer M.

AU - Shah, Jay N.

AU - Lattermann, Christian

N1 - Funding Information: The authors thank the associate dean of research, College of Health Sciences, University of Kentucky, for funding their research through the College of Health Sciences Pilot Study Grant Mechanism. They also thank the University of Kentucky CR-DOC laboratory and Ken Westberry for completing the ELISAs. Finally, they thank Matthew R. Luckett, MD, for his assistance in collecting the serum samples. This research study was supported by the College of Health Sciences Pilot Study Grant Mechanism.

PY - 2011/10

Y1 - 2011/10

N2 - Objective: To determine the intraday and interday reliability of serum cartilage oligomeric matrix protein (sCOMP) in a physically active population with no history of lower extremity surgery. Design: A repeated-measures reliability study was employed to determine the intraday and interday reliability of sCOMP in a physically active cohort. A total of 23 subjects were recruited to the laboratory on 3 separate occasions for nonfasting serum collection. Subjects had no history of lower extremity surgery and were free from acute injury within the last 3 months. Results: Our results indicate strong reliability for both intraday intraclass correlation coefficient (ICC) (0.76) and interday ICC (0.74) sCOMP values. Conclusion: Our results demonstrate that following 30 minutes of inactivity, nonfasting serum samples remain stable over the course of 1 day and between 2 consecutive days in a healthy population with no history of lower extremity surgery. Future research studies are needed to further investigate the magnitude of change in this biomarker for patients with acute articular cartilage damage to determine its appropriateness for use in this population and for varying degrees of articular cartilage severity.

AB - Objective: To determine the intraday and interday reliability of serum cartilage oligomeric matrix protein (sCOMP) in a physically active population with no history of lower extremity surgery. Design: A repeated-measures reliability study was employed to determine the intraday and interday reliability of sCOMP in a physically active cohort. A total of 23 subjects were recruited to the laboratory on 3 separate occasions for nonfasting serum collection. Subjects had no history of lower extremity surgery and were free from acute injury within the last 3 months. Results: Our results indicate strong reliability for both intraday intraclass correlation coefficient (ICC) (0.76) and interday ICC (0.74) sCOMP values. Conclusion: Our results demonstrate that following 30 minutes of inactivity, nonfasting serum samples remain stable over the course of 1 day and between 2 consecutive days in a healthy population with no history of lower extremity surgery. Future research studies are needed to further investigate the magnitude of change in this biomarker for patients with acute articular cartilage damage to determine its appropriateness for use in this population and for varying degrees of articular cartilage severity.

KW - Articular cartilage

KW - Biomarkers

KW - Knee injury

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Determination of the interday and intraday reliability of serum cartilage oligomeric matrix protein in a physically active population

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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