Developing a neonatal acute kidney injury research definition: A report from the NIDDK neonatal AKI workshop

Michael Zappitelli; Namasivayam Ambalavanan; David J. Askenazi; Marva M. Moxey-Mims; Paul L. Kimmel; Robert A. Star; Carolyn L. Abitbol; Patrick D. Brophy; Guillermo Hidalgo; Mina Hanna; Catherine M. Morgan; Tonse N.K. Raju; Patricio Ray; Zayhara Reyes-Bou; Amani Roushdi; Stuart L. Goldstein

doi:10.1038/pr.2017.136

Developing a neonatal acute kidney injury research definition: A report from the NIDDK neonatal AKI workshop

Michael Zappitelli, Namasivayam Ambalavanan, David J. Askenazi, Marva M. Moxey-Mims, Paul L. Kimmel, Robert A. Star, Carolyn L. Abitbol, Patrick D. Brophy, Guillermo Hidalgo, Mina Hanna, Catherine M. Morgan, Tonse N.K. Raju, Patricio Ray, Zayhara Reyes-Bou, Amani Roushdi, Stuart L. Goldstein

Pediatrics

Research output: Contribution to journal › Article › peer-review

212 Scopus citations

Abstract

Research on neonatal AKI definition is evolving and must consider physiology (e.g., developmental GFR increase) while allowing for flexibility to include future validated markers of structural/tissue injury. Neonatal AKI definitions will enable rigorous clinical and translational research. A summary of research recommendations and knowledge gaps is provided in Table 2. Multicenter studies (such as The Neonatal Kidney Collaborative group, formed subsequent to this NIH workshop) to address these knowledge gaps and determine definitions that are most feasible and best predict outcomes are needed (4). Until a widely accepted definition is available, researchers should strive to use rational, physiology-based SCr and urine output definition criteria and clearly describe methods used to define neonatal AKI, in published data, in order to move this field forward.

Original language	English
Pages (from-to)	569-573
Number of pages	5
Journal	Pediatric Research
Volume	82
Issue number	4
DOIs	https://doi.org/10.1038/pr.2017.136
State	Published - Oct 1 2017

Bibliographical note

Publisher Copyright:
© Copyright 2017 International Pediatric Research Foundation, Inc.

Funding

This workshop was sponsored by the NIDDK. The opinions expressed do not necessarily reflect those of the National Institute of Diabetes, Digestive and Kidney Diseases, the National Institutes of Health, the Department of Health and Human Services, or the Government of the United States of America. The corresponding author, M.Z., was supported by a research salary award from the Fonds de Recherche du Québec-Santé.

Funders	Funder number
National Institute of Diabetes and Digestive and Kidney Diseases
Fonds de Recherche du Québec-Santé

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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Zappitelli, M., Ambalavanan, N., Askenazi, D. J., Moxey-Mims, M. M., Kimmel, P. L., Star, R. A., Abitbol, C. L., Brophy, P. D., Hidalgo, G., Hanna, M., Morgan, C. M., Raju, T. N. K., Ray, P., Reyes-Bou, Z., Roushdi, A., & Goldstein, S. L. (2017). Developing a neonatal acute kidney injury research definition: A report from the NIDDK neonatal AKI workshop. Pediatric Research, 82(4), 569-573. https://doi.org/10.1038/pr.2017.136

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abstract = "Research on neonatal AKI definition is evolving and must consider physiology (e.g., developmental GFR increase) while allowing for flexibility to include future validated markers of structural/tissue injury. Neonatal AKI definitions will enable rigorous clinical and translational research. A summary of research recommendations and knowledge gaps is provided in Table 2. Multicenter studies (such as The Neonatal Kidney Collaborative group, formed subsequent to this NIH workshop) to address these knowledge gaps and determine definitions that are most feasible and best predict outcomes are needed (4). Until a widely accepted definition is available, researchers should strive to use rational, physiology-based SCr and urine output definition criteria and clearly describe methods used to define neonatal AKI, in published data, in order to move this field forward.",

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Zappitelli, M, Ambalavanan, N, Askenazi, DJ, Moxey-Mims, MM, Kimmel, PL, Star, RA, Abitbol, CL, Brophy, PD, Hidalgo, G, Hanna, M, Morgan, CM, Raju, TNK, Ray, P, Reyes-Bou, Z, Roushdi, A & Goldstein, SL 2017, 'Developing a neonatal acute kidney injury research definition: A report from the NIDDK neonatal AKI workshop', Pediatric Research, vol. 82, no. 4, pp. 569-573. https://doi.org/10.1038/pr.2017.136

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Developing a neonatal acute kidney injury research definition: A report from the NIDDK neonatal AKI workshop

Abstract

Bibliographical note

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