Development and evaluation of a manganese and iron food frequency questionnaire for pediatrics

Frida B. Zipkin; Grace A. Falciglia; Pierce Kuhnell; Erin N. Haynes

doi:10.3390/ijerph14091060

Development and evaluation of a manganese and iron food frequency questionnaire for pediatrics

Frida B. Zipkin, Grace A. Falciglia, Pierce Kuhnell, Erin N. Haynes

Epidemiology & Environmental Health

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Manganese (Mn) is an essential nutrient, but overexposure can lead to neurotoxicity. Given the essentiality of Mn in the diet, particularly during children’s growth and development, it is imperative to quantify dietary Mn intake in populations that may be exposed to industrial sources of Mn. Dietary absorption of Mn is inversely associated with iron (Fe) stores, yet there is currently no food frequency questionnaire (FFQ) to assess dietary Mn and Fe intake. The study objective was to develop and evaluate the validity of a FFQ to measure dietary Mn and Fe intake in pediatrics by comparing the estimated intakes of Mn and Fe with biomarkers: Mn in blood and hair and Fe in serum. This study utilized a subset of the Communities Actively Researching Exposure Study (CARES) population residing in Guernsey County, Ohio. Dietary Mn was not correlated with either blood or hair Mn; however, dietary Mn and serum ferritin were significantly correlated, with a correlation coefficient of 0.51, p < 0.01. Moreover, dietary Fe and serum ferritin were also significantly correlated, with a correlation coefficient of 0.51, p < 0.01. This FFQ is a valid measurement tool for Fe intake as measured by serum ferritin; however, Mn intake did not correlate with either blood or hair Mn.

Original language	English
Article number	1060
Journal	International Journal of Environmental Research and Public Health
Volume	14
Issue number	9
DOIs	https://doi.org/10.3390/ijerph14091060
State	Published - Sep 14 2017

Bibliographical note

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

Acknowledgments: This research study was supported by NIEHS R01ES016531 and NIH/NCRR 8UL1TR000077-04.

Funders	Funder number
NIH/NCRR	8UL1TR000077-04
National Institute of Environmental Health Sciences (NIEHS)	R01ES016531

Keywords

Appalachian
Development
Diet
Evaluation
Iron
Manganese
Pediatric
Population
Questionnaire
Toxicity

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijerph14091060

Cite this

@article{aea7a5fa3c794c05acf0d6b29401b424,

title = "Development and evaluation of a manganese and iron food frequency questionnaire for pediatrics",

abstract = "Manganese (Mn) is an essential nutrient, but overexposure can lead to neurotoxicity. Given the essentiality of Mn in the diet, particularly during children{\textquoteright}s growth and development, it is imperative to quantify dietary Mn intake in populations that may be exposed to industrial sources of Mn. Dietary absorption of Mn is inversely associated with iron (Fe) stores, yet there is currently no food frequency questionnaire (FFQ) to assess dietary Mn and Fe intake. The study objective was to develop and evaluate the validity of a FFQ to measure dietary Mn and Fe intake in pediatrics by comparing the estimated intakes of Mn and Fe with biomarkers: Mn in blood and hair and Fe in serum. This study utilized a subset of the Communities Actively Researching Exposure Study (CARES) population residing in Guernsey County, Ohio. Dietary Mn was not correlated with either blood or hair Mn; however, dietary Mn and serum ferritin were significantly correlated, with a correlation coefficient of 0.51, p < 0.01. Moreover, dietary Fe and serum ferritin were also significantly correlated, with a correlation coefficient of 0.51, p < 0.01. This FFQ is a valid measurement tool for Fe intake as measured by serum ferritin; however, Mn intake did not correlate with either blood or hair Mn.",

keywords = "Appalachian, Development, Diet, Evaluation, Iron, Manganese, Pediatric, Population, Questionnaire, Toxicity",

author = "Zipkin, {Frida B.} and Falciglia, {Grace A.} and Pierce Kuhnell and Haynes, {Erin N.}",

note = "Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2017",

month = sep,

day = "14",

doi = "10.3390/ijerph14091060",

language = "English",

volume = "14",

number = "9",

}

TY - JOUR

T1 - Development and evaluation of a manganese and iron food frequency questionnaire for pediatrics

AU - Zipkin, Frida B.

AU - Falciglia, Grace A.

AU - Kuhnell, Pierce

AU - Haynes, Erin N.

PY - 2017/9/14

Y1 - 2017/9/14

N2 - Manganese (Mn) is an essential nutrient, but overexposure can lead to neurotoxicity. Given the essentiality of Mn in the diet, particularly during children’s growth and development, it is imperative to quantify dietary Mn intake in populations that may be exposed to industrial sources of Mn. Dietary absorption of Mn is inversely associated with iron (Fe) stores, yet there is currently no food frequency questionnaire (FFQ) to assess dietary Mn and Fe intake. The study objective was to develop and evaluate the validity of a FFQ to measure dietary Mn and Fe intake in pediatrics by comparing the estimated intakes of Mn and Fe with biomarkers: Mn in blood and hair and Fe in serum. This study utilized a subset of the Communities Actively Researching Exposure Study (CARES) population residing in Guernsey County, Ohio. Dietary Mn was not correlated with either blood or hair Mn; however, dietary Mn and serum ferritin were significantly correlated, with a correlation coefficient of 0.51, p < 0.01. Moreover, dietary Fe and serum ferritin were also significantly correlated, with a correlation coefficient of 0.51, p < 0.01. This FFQ is a valid measurement tool for Fe intake as measured by serum ferritin; however, Mn intake did not correlate with either blood or hair Mn.

AB - Manganese (Mn) is an essential nutrient, but overexposure can lead to neurotoxicity. Given the essentiality of Mn in the diet, particularly during children’s growth and development, it is imperative to quantify dietary Mn intake in populations that may be exposed to industrial sources of Mn. Dietary absorption of Mn is inversely associated with iron (Fe) stores, yet there is currently no food frequency questionnaire (FFQ) to assess dietary Mn and Fe intake. The study objective was to develop and evaluate the validity of a FFQ to measure dietary Mn and Fe intake in pediatrics by comparing the estimated intakes of Mn and Fe with biomarkers: Mn in blood and hair and Fe in serum. This study utilized a subset of the Communities Actively Researching Exposure Study (CARES) population residing in Guernsey County, Ohio. Dietary Mn was not correlated with either blood or hair Mn; however, dietary Mn and serum ferritin were significantly correlated, with a correlation coefficient of 0.51, p < 0.01. Moreover, dietary Fe and serum ferritin were also significantly correlated, with a correlation coefficient of 0.51, p < 0.01. This FFQ is a valid measurement tool for Fe intake as measured by serum ferritin; however, Mn intake did not correlate with either blood or hair Mn.

KW - Appalachian

KW - Development

KW - Diet

KW - Evaluation

KW - Iron

KW - Manganese

KW - Pediatric

KW - Population

KW - Questionnaire

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=85029627961&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029627961&partnerID=8YFLogxK

U2 - 10.3390/ijerph14091060

DO - 10.3390/ijerph14091060

M3 - Article

C2 - 28906436

AN - SCOPUS:85029627961

SN - 1661-7827

VL - 14

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 9

M1 - 1060

ER -

Development and evaluation of a manganese and iron food frequency questionnaire for pediatrics

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this