TY - JOUR
T1 - Development of an implantable artificial lung
T2 - Challenges and progress
AU - Zwischenberger, Joseph B.
AU - Anderson, Carryn M.
AU - Cook, Keith E.
AU - Lick, Scott D.
AU - Mockros, Lyle F.
AU - Bartlett, Robert H.
PY - 2001
Y1 - 2001
N2 - Unlike dialysis, which functions as a bridge to renal transplantation, or a ventricular assist device, which serves as a bridge to cardiac transplantation, no suitable bridge to lung transplantation exists. Our goal is to design and build an ambulatory artificial lung that can be perfused entirely by the right ventricle and completely support the metabolic O2 and CO2 requirements of an adult. Such a device could realize a substantial clinical impact as a bridge to lung transplantation, as a support device immediately post-lung transplant, and as a rescue and/or supplement to mechanical ventilation during the treatment of severe respiratory failure. Research on the artificial lung has focused on the design, mode of attachment to the pulmonary circulation, and intracorporeal versus paracorporeal placement of the device.
AB - Unlike dialysis, which functions as a bridge to renal transplantation, or a ventricular assist device, which serves as a bridge to cardiac transplantation, no suitable bridge to lung transplantation exists. Our goal is to design and build an ambulatory artificial lung that can be perfused entirely by the right ventricle and completely support the metabolic O2 and CO2 requirements of an adult. Such a device could realize a substantial clinical impact as a bridge to lung transplantation, as a support device immediately post-lung transplant, and as a rescue and/or supplement to mechanical ventilation during the treatment of severe respiratory failure. Research on the artificial lung has focused on the design, mode of attachment to the pulmonary circulation, and intracorporeal versus paracorporeal placement of the device.
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U2 - 10.1097/00002480-200107000-00003
DO - 10.1097/00002480-200107000-00003
M3 - Review article
C2 - 11482477
AN - SCOPUS:0034933249
SN - 1058-2916
VL - 47
SP - 316
EP - 320
JO - ASAIO Journal
JF - ASAIO Journal
IS - 4
ER -