Development of Chagas cardiac manifestations among texas blood donors

Melissa N. Garcia, Kristy O. Murray, Peter J. Hotez, Susan N. Rossmann, Rodion Gorchakov, Alejandra Ontiveros, Laila Woc-Colburn, Maria Elena Bottazzi, Charles E. Rhodes, Christie M. Ballantyne, David Aguilar

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Chagas disease, infection with the parasite Trypanosoma cruzi, has recently been identified as an important emerging parasitic disease in the United States. To describe the cardiac abnormalities in T. cruzi-positive blood donors in southeastern Texas, a pilot study of donors who had screened positive from 2007 to 2012 was performed. This one-time assessment included (1) a questionnaire to evaluate the source of infection, cardiac symptoms, and health co-morbidities; (2) electrocardiography; (3) echocardiography if electrocardiographic findings were abnormal; and (4) measurement of a high-sensitivity troponin T biomarker. Of those with confirmed infection, 41% (7 of 17) had electrocardiographic abnormalities consistent with Chagas cardiomyopathy. In addition, 36% (6 of 17) were suspected to be locally acquired cases. High-sensitivity troponin T serum levels increased with cardiac severity. In conclusion, cardiologists should consider Chagas disease in their differential diagnoses for patients who may have clinically compatible electrocardiographic changes or nonischemic cardiomyopathy, even if the patients have no histories of residing in Chagas-endemic countries.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalAmerican Journal of Cardiology
Issue number1
StatePublished - Jan 1 2015

Bibliographical note

Funding Information:
This study was funded by the Baylor College of Medicine Cardiovascular Research Institute .

Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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