Development of novel n-isopropylacrylamide (Nipaam) based hydrogels with varying content of chrysin multiacrylate

Shuo Tang, Martha Floy, Rohit Bhandari, Thomas Dziubla, J. Zach Hilt

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A series of novel temperature responsive hydrogels were synthesized by free radical polymerization with varying content of chrysin multiacrylate (ChryMA). The goal was to study the impact of this novel polyphenolic-based multiacrylate on the properties of N-isopropylacrylamide (NIPAAm) hydrogels. The temperature responsive behavior of the copolymerized gels was characterized by swelling studies, and their lower critical solution temperature (LCST) was characterized through differential scanning calorimetry (DSC). It was shown that the incorporation of ChryMA decreased the swelling ratios of the hydrogels and shifted their LCSTs to a lower temperature. Gels with different ChryMA content showed different levels of response to temperature change. Higher content gels had a broader phase transition and smaller temperature response, which could be attributed to the increased hydrophobicity being introduced by the ChryMA.

Original languageEnglish
Article number40
Issue number4
StatePublished - Dec 2017

Bibliographical note

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.


  • Hydrogel
  • LCST
  • N-isopropylacrylamide

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Polymers and Plastics


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